FlyBase Allele Report: Dmel\v[1]

General Information

Symbol

Dmel\v¹

Species

D. melanogaster

Name

FlyBase ID

FBal0017656

Feature type

allele

Associated gene

Dmel\v

Associated Insertion(s)

412{}v¹

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Searles et al., 1990)

Mutagen

spontaneous

(Pret and Searles, 1991)

Progenitor genotype

Associated Insertion(s)

412{}v¹

Cytology

Description

Mutation created by the insertion of a 412 retrotransposon into the 5' untranslated region of the first exon.

(Pret and Searles, 1991)

Identical insertion of 7.5kb 412 into first exon of 83 nucleotides.

(Fridell et al., 1990)

Insertion of a 412 element between base pairs 1150 and 1151, 36bp downstream of the major transcription start site, and 21bp upstream of the translation start site. The direction of transcription of the 412 element is opposite to the direction of v transcription.

(Searles et al., 1990)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:10,924,006..10,924,006 [-]

(Cavaliere et al., 2020, Pret and Searles, 1991, Fridell et al., 1990, Searles et al., 1990, Voelker et al., 1989)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

X52763

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color

visible | recessive

Phenotype Manifest In

adult heart

(Beasley and Dowse, 2016)

adult heart | male (with Df(1)v-L15)

(Beasley and Dowse, 2016)

ocellus pigment granule

pigment cell

Detailed Description

Statement

Reference

21-days old v¹ mutant adults raised at 29[o]C do not show significantly changes in PPL1 neurons, as compared to age-matched controls.

(Cunningham et al., 2018)

v¹ adult heterozygotes as well as homozygotes display significantly slower heartbeat across temperatures ranging from 20[o]C to 37[o]C and the average heartbeat action across temperatures of v¹ mutant prepupae is more rhythmic compared to wild-type controls. The number of inter-beat intervals lasting more than 1 sec is not significantly different between v¹ mutants of either sex and the controls, although genetic background plays a significant role as v¹ mutant males from a line that hasn't been outcrossed show highly increased count of these heart stoppages.

The heartbeat of v¹/Df(1)v-L15 males is significantly more rhythmic relative to control males at 37[o]C and also on average across temperatures.

(Beasley and Dowse, 2016)

Ocelli are unpigmented. v¹ blocks the pigmentation of rc² flies.

(Tearle, 1991)

Trace amounts of wild type sized transcripts present in mutants (Searles et al., 1990).

(Fridell et al., 1990)

vermilion eyes.

(Zhimulev et al., 1987)

v¹ eye discs develop wild-type pigmentation when transplanted into wild-type larvae.

(Beadle and Ephrussi, 1936)

Non-autonomous in v⁺//v¹ gynandromorphs.

(Sturtevant, 1932)

Eye colour: bright red. Eye colour: white, with bw¹. Ocellus colour: colourless.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

v[+]/v¹ is an enhancer of chemical sensitive phenotype of Gk1^RNAi.UAS, Scer\GAL4^c564

(Wightman et al., 2012)

Other

Statement

Reference

v¹, w^cf2 has abnormal eye color phenotype

(Kaufman, 1969)

VhaAC39-1^cho-1, v¹ has abnormal eye color phenotype

(Sturtevant, 1955)

v¹, w^a has abnormal eye color | dominant phenotype

(Braver, 1953)

lz⁵⁹, v¹ has abnormal eye color phenotype

Phenotype Manifest In

Suppressed by

Statement

Reference

v¹ has phenotype, suppressible by su(sable)¹

(Searles et al., 1990)

v¹ has phenotype, suppressible by su(sable)⁵⁰

(Voelker et al., 1989)

v¹ has phenotype, suppressible by su(sable)⁵²

(Voelker et al., 1989)

v¹ has phenotype, suppressible by su(sable)⁵⁴

(Voelker et al., 1989)

v¹ has phenotype, suppressible by su(sable)⁵⁵

(Voelker et al., 1989)

v¹ has phenotype, suppressible by su(sable)⁵⁶

(Voelker et al., 1989)

v¹ has phenotype, suppressible by su(sable)⁵⁷

(Voelker et al., 1989)

v¹ has phenotype, suppressible by su(sable)⁵⁹

(Voelker et al., 1989)

v¹ has phenotype, suppressible by su(sable)⁶⁰

(Voelker et al., 1989)

v¹ has phenotype, suppressible by su(sable)⁶¹

(Voelker et al., 1989)

v¹ has phenotype, suppressible by su(sable)⁶²

(Voelker et al., 1989)

v¹ has phenotype, suppressible by su(sable)⁶³

(Voelker et al., 1989)

v¹ has phenotype, suppressible by su(sable)⁵³

(Voelker et al., 1989)

v¹ has phenotype, suppressible by su(sable)⁶⁴

(Voelker et al., 1989)

v¹ has phenotype, suppressible by su(sable)⁶⁵

(Voelker et al., 1989)

v¹ has phenotype, suppressible by su(sable)⁶⁷

(Voelker et al., 1989)

v¹ has phenotype, suppressible by su(sable)⁶⁹

(Voelker et al., 1989)

v¹ has phenotype, suppressible by su(sable)⁷⁰

(Voelker et al., 1989)

v¹ has phenotype, suppressible by su(sable)⁵⁸

(Voelker et al., 1989)

v¹ has phenotype, suppressible by su(sable)⁶⁶

(Voelker et al., 1989)

v¹ has phenotype, suppressible by su(sable)⁶⁸

(Voelker et al., 1989)

v¹ has phenotype, suppressible by su(sable)³⁹

(Voelker et al., 1989)

v¹ has phenotype, suppressible by su(sable)⁴⁸

(Voelker et al., 1989)

v¹ has phenotype, suppressible by su(sable)⁴⁹

(Voelker et al., 1989)

v¹ has phenotype, suppressible by su(sable)⁵¹

(Voelker et al., 1989)

Other

Statement

Reference

v¹, w^cf2 has pigment cell phenotype

(Kaufman, 1969)

VhaAC39-1^cho-1, v¹ has pigment cell phenotype

(Sturtevant, 1955)

lz⁵⁹, v¹ has pigment cell phenotype

Additional Comments

Genetic Interactions

Statement

Reference

The glycerol hypersensitivity of flies expressing Gyk^{dsRNA.Scer\UAS} under the control of Scer\GAL4^c564 (seen as a reduction in survival on a glycerol only food source) is enhanced if the flies are also heterozygous for v¹.

(Wightman et al., 2012)

Eye colour: orange when homozygous with w^cf2, in both males and females.

(Kaufman, 1969)

Eye colour: yellowish, with cho¹.

(Sturtevant, 1955)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (2)

Holtzman, S. and Kaufman, T. (2013)

Mutant

Wild-type

Stocks (28,032)

Bloomington

170

Df(1)y-ac, v¹

1509

y¹ v¹

bo¹ v¹

peb¹ v¹

395

v¹; sf²

668

v¹; bw¹

1031

3489

51188

101249

y¹ v¹

106355

y¹ v¹

105720

peb¹ v¹

More stocks available...

Notes on Origin

Discoverer

Morgan, Nov. 1910.

Comments

The distribution of ry protein in the tissues of the adult fly is altered in this mutant.

(Reaume et al., 1991)

External Crossreferences and Linkouts ( 1 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

X52763

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

(Sturtevant, 1955)

v¹

(Bragina et al., 2025, Zhuravlev et al., 2025, Cavaliere et al., 2020, Cunningham et al., 2018, Groen et al., 2018, Beasley and Dowse, 2016, Kondo and Ueda, 2013, Wightman et al., 2012, Harris et al., 2011, Popodi et al., 2010-, Christensen et al., 2008.6.11, Christensen et al., 2008.7.11, Christensen et al., 2008.12.28)

Name Synonyms

Secondary FlyBase IDs

References (57)

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