FB2026_02 , released June 18, 2026
Allele: Dmel\mah1
Open Close
General Information
Symbol
Dmel\mah1
Species
D. melanogaster
Name
FlyBase ID
FBal0011977
Feature type
allele
Associated gene
Dmel\mah
Associated Insertion(s)
roo{}mah1
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    roo{}mah1
    Cytology
    Description

    Amino acid replacement: I460T.

    (Grant et al., 2016)

    An insertion of 433 bp corresponding to a roo LTR, including a duplication of a 5-bp insert sequence, in the fifth exon of mah. This is linked to a nonsynonymous T>C substitution at 3R:24949334 (r6) causing an I460T change, if that position were transcribed and translated in the presence of the roo LTR element.

    (Grant et al., 2016)

    Nucleotide substitution: T24949334C.

    (Grant et al., 2016)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3R:24,949,334..24,949,334 [+]
    Nucleotide change:

    T24949334C

    Amino acid change:

    I460T | mah-PA

    Reported amino acid change:

    I460T

    (Grant et al., 2016)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        mah1 homozygous adults display eye color defects ('mahogany' eye color).

        (Grant et al., 2016)

        Eyes contain 77% normal red pigment and 102% normal brown pigment.

        (Nolte, 1955)

        Malpighian tubule colour: wild-type.

        (Beadle, 1937)

        Eye colour: translucent brown in young flies, changing toward wild type and becoming dark brown with age.

        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        mah1 is rescued by mahUAS.cGa/Scer\GAL4GMR.PF

        (Grant et al., 2016)
        Comments

        The eye color defect ('mahogany' eyes) characteristic for mah1 homozygous adults is rescued by expression of mahUAS.cGa under the control of Scer\GAL4GMR.PF.

        (Grant et al., 2016)
        Images (2)
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        mah1
        (Grant et al., 2016)
        Name Synonyms
        Secondary FlyBase IDs
          References (3)