FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Mhc11
Open Close
General Information
Symbol
Dmel\Mhc11
Species
D. melanogaster
Name
FlyBase ID
FBal0012252
Feature type
allele
Associated gene
Dmel\Mhc
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Nucleotide substitution: T9067A. This changes the 5' splice junction signal of exon 9a from GT to GA (which is not recognised by the splicing machinery).

    (Kronert et al., 1991)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    2L:16,775,383..16,775,383 [+]
    Nucleotide change:

    T16775383A

    Reported nucleotide change:

    T9067A

    Comment:

    Mutation in splice donor sequence from GT to GA

    (Kronert et al., 1991)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        The indirect flight muscles lack thick filaments. The large and small cells of the jump muscle appear normal, and jumping ability is unimpaired.

        (Kronert et al., 1991)

        Mhc accumulation in leg muscles is unaffected and the effect on thick filament accumulation in the jump muscle is less severe then Mhc10.

        (Collier et al., 1990)

        Indirect flight muscles accumulate little or no MHC, have no thick filaments, and show no organized myofibrils. No apparent effect on TDT; unique among alleles in being capable of jumping. Leg muscle MHC found in normal amounts (O'Donnell, Collier, Mogami and Bernstein, 1989). homozygous viable

        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer

        Mogami.

        Comments
        Comments

        Exons 15a and 15b have been sequenced and are wild-type.

        (Collier et al., 1990)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        Mhc11
        Name Synonyms
        Secondary FlyBase IDs
          References (4)