FB2026_03 , released September 17, 2026
Allele: Dmel\ms(3)HO5A1
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General Information
Symbol
Dmel\ms(3)HO5A1
Species
D. melanogaster
Name
FlyBase ID
FBal0012542
Feature type
allele
Associated gene
ms(3)HO5A
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Nishida, 1980)
Progenitor genotype
Cytology

Polytene chromosomes normal.

(Nishida, 1980)
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous males have rudimentary testes, in which the growth of the anterior region is greatly reduced, although the formation of the basal region and their attachment to the duct system appears normal. These testes are filled with young primary spermatocytes and acellular material. A few spermatid bundles are seen.

      (Nishida, 1980)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      ms(3)HO5A1 has male sterile | recessive phenotype, suppressible by su(msm1)1

      (Nishida, 1980)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      ms(3)HO5A1 has testis phenotype, suppressible by su(msm1)1

      (Nishida, 1980)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Males homozygous for both ms(3)HO5A1 and su(msm1)1 have spiral shaped testes, but these testes are considerably shorter and thinner than those of normal males. Elongated spermatid bundles are seen in these testes. This suppression is incomplete, as 8% of su(msm1)1 ms(3)HO5A1 double homozygous males have rudimentary testes. 7% of su(msm1)1 ms(3)HO5A1 double homozygous males are fertile, suggesting either that the ms(3)HO5A1 allele is leaky, or partial dominance of su(msm1)1 over its wild-type allele.

      (Nishida, 1980)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Induced with: ms(3)HO5B1. Induced with: fs(3)HO5A1. Induced with: fs(3)HO5B1.

      (Nishida, 1980)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ms(3)HO5A1
      ms(3)m15A
      (Nishida, 1980)
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0012545
      References (1)