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General Information
Symbol
Dmel\mu21
Species
D. melanogaster
Name
FlyBase ID
FBal0012569
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
mu2a
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

mu21 and mu21/Df(3L)Aprt-1 mutants have a similar frequency of single-strand annealing repair (SSA) compared to controls in a P{wIw.FRT} hemizygous assay to study DNA double-stranded break repair when assayed at 38oC, but show an increased SSA frequency compared to controls when assayed at 32oC.

Homozygous larvae do not show higher sensitivity to killing by methyl methanesulfonate or radiation than wild type. mu21 shows a 6-fold increase in the frequency of total y- and f36a spots and a 17-fold increase in the frequency of twin spots in the abdomen of unirradiated y- + / + f36a females compared to controls. γ irradiation has no discernible effect on the frequency of spots in mu21 females in contrast to wild type.

Lesions induced by γ rays in sperm chromosomes are repaired after fertilisation, while lesions induced in oocyte chromosomes are shunted instead to a mechanism that stabilises broken chromosome ends.

Irradiation of females homozygous for mu21 with low doses of X rays produces substantial numbers of terminal deficiencies for all chromosome arms <up>see for example Df(1)yT</up>; irradiation of heterozygous females produces frequencies of deficiencies intermediate between those obtained from homozygous mu21 and wild-type females. Extents of deficiencies limited only by the ability to recover them in viable offspring. Incidence of terminal losses linear with dose; such deficiencies visible cytologically and can be shown by in situ hybridization to lack sequences characteristically present at the termini of chromosome arms. Irradiation of mu21 females does not increase the incidence of either interstitial deficiencies or sex-linked lethal mutations. Irradiation of mu21 males does not increase the frequency of deficiencies.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Not rescued by

mu21 is not rescued by mu2tA6c

Comments
Images (0)
Mutant
Wild-type
Stocks (3)
Notes on Origin
Discoverer

M.M. Green.

Comments
Comments

Df(3R)sbd105 fails to complement mu21.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (6)