FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mus101D1
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General Information
Symbol
Dmel\mus101D1
Species
D. melanogaster
Name
FlyBase ID
FBal0012589
Feature type
allele
Associated gene
Dmel\mus101
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description

Partial deletion of mus101 coding sequences (c.3168-3659del, p.K1056fs).

(Kondo and Perrimon, 2011)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous eye discs are defective in ionising-radiation induced G2 arrest.

      Homozygous eye discs show defects in hydroxyurea-induced G2 arrest.

      (Lee et al., 2012)

      X-ray irradiation of wild-type third-instar wing imaginal discs induces cell cycle arrest within 1 hour. In contrast, X-ray irradiation of mus101D1 mutant larvae fails to induce cell cycle arrest.

      (Kondo and Perrimon, 2011)

      mus101D1 mutants have a similar frequency of single-strand annealing repair (SSA) compared to controls in a P{wIw.FRT} hemizygous assay to study DNA double-stranded break repair when assayed at 32oC or 38oC.

      (Wei and Rong, 2007)

      Mutants are sensitive to MMS.

      (Yamamoto et al., 2000)

      Excision repair capacity is normal and post-replication repair capacity is partly deficient.

      (Ferro and Eeken, 1993)

      mus101ts1/mus101D2 females are hypersensitive to killing by MMS and have reduced fertility. Homozygous females have reduced fertility. Chromosome condensation is abnormal in hemizygous third instar larval ganglia.

      (Smith et al., 1985)

      Homozygotes and hemizygotes do not show an increased frequency of spontaneous chromosome aberrations in neuroblast metaphases compared to wild-type larvae.

      (Gatti, 1979)

      female-fertile

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      mus101lcd

      (Yamamoto et al., 2000)

      mus101SM

      (Yamamoto et al., 2000)
      Rescued by

      mus101D1 is rescued by mus101+t9

      (Yamamoto et al., 2000)
      Not rescued by

      mus101D1 is not rescued by mus101tB10

      (Yamamoto et al., 2000)
      Comments

      mus101SM and mus101lcd fail to complement the mutagen sensitivity of mus101D1.

      (Yamamoto et al., 2000)
      Images (0)
      Mutant
      Wild-type
      Stocks (3)
      Notes on Origin
      Discoverer

      Boyd.

      Comments
      Comments

      Complements: l(1)dd4xr16

      (Barbosa et al., 2000)

      Homozygotes have normal excision repair capabilities, but postreplication repair is reduced compared to wild-type. Homozygous cultured cells respond to UV irradiation with normal reductions in thymidine incorporation and with the synthesis of abnormally short nascent DNA.

      (Brown and Boyd, 1981)

      mus101D1 has no detectable effect on the recovery of chromosomes undergoing P-element transposition.

      (Banga et al., 1991)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      101D1
      (Gatti, 1979)
      mus(1)101D1
      (Vogel, 1992, Olsen and Green, 1982)
      mus101D1
      (Colmenares et al., 2017, Lee et al., 2012, Kondo and Perrimon, 2011, Kotlovanova et al., 2008, Wei and Rong, 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (17)