Similarly to wild-type third-instar larvae, X-ray irradiation of mus101K451 mutants induces cell cycle arrest in wing imaginal disc cells.
Mutants are sensitive to MMS.
Morphological defects: substantial underproduction and disruption of the endochorion, correlated with the underproduction of 6 major chorion protein gene products: Cp15, Cp16, Cp18, Cp19, Cp36 and Cp38.
females produce morphologically abnormal eggs female-sterile Reduced viability, especially of females; abnormalities of posterior legs, also especially in females. fs(1)K451/Df(1)g does not survive. Homozygous females produce eggs with short thin dorsal appendages and ultrastructurally defective chorions. All major chorion proteins underproduced owing to failure of chorion protein gene amplification. Cp genes on the third chromosome more severely affected than those on the X (Orr, Komitopoulou and Kafatos, 1984). In mosaic experiments fs(1)K451 behaves as a locus required in both somatic and germinal tissues (Perrimon and Gans, 1983).