FlyBase Allele Report: Dmel\mus301[D1]

General Information

Symbol

Dmel\mus301^D1

Species

D. melanogaster

Name

FlyBase ID

FBal0012636

Feature type

allele

Associated gene

Dmel\mus301

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Boyd et al., 1981)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

chemical sensitive (with mus301⁰⁹⁴)

(McCaffrey et al., 2006)

chemical sensitive | recessive

(Boyd et al., 1981)

radiation sensitive

(Gamo et al., 1990, Oliveri et al., 1990)

Phenotype Manifest In

egg | maternal effect (with Df(3L)66C-G28)

(McCaffrey et al., 2006)

egg | maternal effect (with mus301⁰⁹⁴)

(McCaffrey et al., 2006)

egg | maternal effect (with mus301⁴²²)

(McCaffrey et al., 2006)

egg | maternal effect (with mus301⁶⁶⁰)

(McCaffrey et al., 2006)

karyosome (with Df(3L)66C-G28)

(McCaffrey et al., 2006)

karyosome (with mus301⁰⁹⁴)

(McCaffrey et al., 2006)

karyosome (with mus301⁴²²)

(McCaffrey et al., 2006)

karyosome (with mus301⁶⁶⁰)

(McCaffrey et al., 2006)

oocyte nucleus (with Df(3L)66C-G28)

(McCaffrey et al., 2006)

oocyte nucleus (with mus301⁰⁹⁴)

(McCaffrey et al., 2006)

oocyte nucleus (with mus301⁴²²)

(McCaffrey et al., 2006)

Detailed Description

Statement

Reference

mus301^D1/mus301^D4 mutants have a similar frequency of single-strand annealing repair (SSA) compared to controls in a P{wIw.FRT} hemizygous assay to study DNA double-stranded break repair when assayed at 32^oC or 38^oC.

(Wei and Rong, 2007)

100% of mus301^D1/Df(3L)66C-G28 egg chambers have a mutant karyosome and 3% have misplaced oocytes. 36% of eggs laid by mus301^D1/Df(3L)66C-G28 females are ventralised.

100% of mus301⁰⁹⁴/mus301^D1 egg chambers have a mutant karyosome and 2% have misplaced oocytes. 21% of eggs laid by mus301⁰⁹⁴/mus301^D1 females are ventralised.

100% of mus301⁴²²/mus301^D1 egg chambers have a mutant karyosome and 2% have misplaced oocytes. 57% of eggs laid by mus301⁴²²/mus301^D1 females are ventralised.

98% of mus301⁶⁶⁰/mus301^D1 egg chambers have a mutant karyosome. 45% of eggs laid by mus301⁶⁶⁰/mus301^D1 females are ventralised.

mus301⁰⁹⁴/mus301^D1 larvae are sensitive to MMS compared to controls.

(McCaffrey et al., 2006)

Flies are hypersensitive to γ-ray knockdown.

(Gamo et al., 1990)

Flies are sensitive to X rays.

(Oliveri et al., 1990)

Hypersensitive to methyl methanesulfonate. Sensitive to 0.008% HN2. Homozygous females show an increased frequency of chromosome loss.

(Boyd et al., 1981)

fertile

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Has no effect on the frequency of X-Y chromosome nondisjunction seen in Df(1)X-1-53B males, but shows a significant enhancement of meiotic drive in these flies compared to controls.

(McKee et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

mus301⁰⁹⁴

(Ghabrial and Schupbach, 1999)

Comments

Images (0)

Mutant

Wild-type