spn-C, spnC, spindle-C
Gene model reviewed during 5.45
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mus301 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\mus301 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of mus301 anon-WO0118547.354 was sequence comparison ( date:051113 ).
mus301 is involved in chromosome segregation in meiosis and in the repair of double-strand-DNA breaks in both meiotic and mitotic cells.
Area matching Drosophila EST AI518328.
Analysis of mutants of the 5 spindle genes (spn-A, spn-B, mus301, spn-D and spn-E) reveals that the group of genes is required for each of the symmetry-breaking steps that generate polarity during axis formation. spn-E is required for the localisation of fs(1)K10, bcd and osk mRNAs, spn-A. spn-B, mus301 and spn-D play an indirect role in this process.
Analysis of egg chambers in mus301 mutants led to the conclusion that AP polarity within the oocyte is defined by the position of the oocyte in the egg chamber.
Larval survival hypersensitive to exposure to X rays (Oliveri, Harris and Boyd, 1990), methyl methanesulfonate and nitrogen mustard. When fertile, homozygous females exhibit elevated frequencies of nondisjunction.