FlyBase Allele Report: Dmel\mus301[D4]

General Information

Symbol

Dmel\mus301^D4

Species

D. melanogaster

Name

FlyBase ID

FBal0012639

Feature type

allele

Associated gene

Dmel\mus301

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Boyd et al., 1981)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

chemical sensitive (with mus301⁰⁹⁴)

(McCaffrey et al., 2006)

chemical sensitive | recessive

(Boyd et al., 1981)

viable

(Merigliano et al., 2017)

Phenotype Manifest In

egg | maternal effect (with Df(3L)66C-G28)

(McCaffrey et al., 2006)

egg | maternal effect (with mus301^D2)

(McCaffrey et al., 2006)

egg chorion | maternal effect (with mus301⁰⁹⁴)

(Ghabrial and Schupbach, 1999)

karyosome (with Df(3L)66C-G28)

(McCaffrey et al., 2006)

karyosome (with mus301^D2)

(McCaffrey et al., 2006)

oocyte (with mus301^D2)

(McCaffrey et al., 2006)

oocyte nucleus (with Df(3L)66C-G28)

(McCaffrey et al., 2006)

oocyte nucleus (with mus301^D2)

(McCaffrey et al., 2006)

Detailed Description

Statement

Reference

mus301^D1/mus301^D4 mutants have a similar frequency of single-strand annealing repair (SSA) compared to controls in a P{wIw.FRT} hemizygous assay to study DNA double-stranded break repair when assayed at 32^oC or 38^oC.

(Wei and Rong, 2007)

100% of mus301^D4/Df(3L)66C-G28 egg chambers have a mutant karyosome and 1% have misplaced oocytes. 69% of eggs laid by mus301^D4/Df(3L)66C-G28 females are ventralised.

99% of mus301^D2/mus301^D4 egg chambers have a mutant karyosome, 15% have misplaced oocytes and 12% have small oocytes. 21% of eggs laid by mus301^D2/mus301^D4 females are ventralised.

mus301⁰⁹⁴/mus301^D4 larvae are sensitive to MMS compared to controls.

(McCaffrey et al., 2006)

Sensitive to 0.008% HN2 and 0.025% methyl methanesulfonate.

(Boyd et al., 1981)

female-sterile

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

mus301^D4, tws⁴³⁰ has lethal - all die before end of first instar larval stage phenotype

(Merigliano et al., 2017)

Phenotype Manifest In

Suppressed by

Statement

Reference

mus301^D4/mus301⁰⁹⁴ has egg chorion | maternal effect phenotype, suppressible | maternal effect by mei-W68^unspecified/Df(2R)LL5

(Ghabrial and Schupbach, 1999)

mus301^D4/mus301⁰⁹⁴ has egg chorion | maternal effect phenotype, suppressible | maternal effect by mei-41^D3/mei-41^D3

(Ghabrial and Schupbach, 1999)

mus301^D4/mus301⁰⁹⁴ has egg chorion | maternal effect phenotype, suppressible | maternal effect | partially by mei-41[+]/mei-41^D3

(Ghabrial and Schupbach, 1999)

Additional Comments

Genetic Interactions

Statement

Reference

mus301^D3/mus301^D4 has no effect on the frequency of X-Y chromosome nondisjunction seen in Df(1)X-1-53B males, but shows a significant enhancement of meiotic drive in these flies compared to controls.

(McKee et al., 2000)

The eggshell patterning defects of eggs derived from mus301^D4/mus301⁰⁹⁴ females are suppressed if the females also carry mei-W68^unspecified/Df(2R)LL5, mei-41^D3/+ or mei-41^D3/mei-41^D3. drive in these flies compared to controls.