FB2026_02 , released June 18, 2026
Allele: Dmel\PolQD1
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General Information
Symbol
Dmel\PolQD1
Species
D. melanogaster
Name
FlyBase ID
FBal0012655
Feature type
allele
Associated gene
Dmel\PolQ
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Boyd et al., 1981)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Defective in levels of nuclease 3, which is apparently active in the repair of DNA cross-links.

      (Boyd et al., 1990)

      Larval survival hypersensitive to exposure to X rays and nitrogen mustard.

      (Oliveri et al., 1990)

      Displays hypermutability to alkylating agents; defective both in alkylation and UV excision repair pathways.

      (Smith and Dusenbery, 1988)

      Partially deficient in post-replication repair and excision; DNA synthesis modified.

      (Boyd and Shaw, 1982, Boyd and Harris, 1981)

      Sensitive to 0.002% HN2. Not sensitive to 0.125% methyl methanesulfonate.

      (Boyd et al., 1981)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      mus308D1/mus308D5 or mus308D1/mus308D4 has no effect on the frequency of X-Y chromosome nondisjunction seen in Df(1)X-1-53B males, but shows a significant enhancement of meiotic drive in these flies compared to controls.

      (McKee et al., 2000)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      308D1
      (McKee et al., 2000)
      DNApol-θD1
      PolQD1
      mus308D1
      Name Synonyms
      Secondary FlyBase IDs
        References (7)