FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Nfa-3
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General Information
Symbol
Dmel\Nfa-3
Species
D. melanogaster
Name
FlyBase ID
FBal0012864
Feature type
allele
Associated gene
Dmel\N
Associated Insertion(s)
springer{}Nfa-3
Carried in Construct
Also Known As
fa3
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
(Grimwade et al., 1985, Artavanis-Tsakonas et al., 1983)
Progenitor genotype
Associated Insertion(s)
springer{}Nfa-3
Cytology
Description

Insertion springer into the second intron.

(Gorman and Girton, 1992)

Insertion of a transposable element into an intronic region between exons B and C of N.

(Ramos et al., 1989)

Insert stated as cause: middle repetitive DNA (inserted between coordinates -8.4 and -10.9, zero coordinate is defined as the centre of the 2.2kb EcoRI fragment that encompasses the N76b8 inversion breakpoint).

(Grimwade et al., 1985)

springer at -11.9 to -11.2

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Sex combs have a few extra bristles, bristles that are not linearly arranged and rough eyes.

      (Gorman and Girton, 1992)

      Retina defects are associated with optic lobe defects in 83.8% of homozygous Nfa-3 retina clones generated by somatic recombination. The arrangement of ommatidia is abnormal in homozygous clones in the retina. A disruption of the fenestrated zone and laminar cortex, and a few small vacuoles in the lamina neuropil can be seen in the underlying optic lobe if it is defective.

      (Markopoulou and Artavanis-Tsakonas, 1991)

      Eyes equally rough in both sexes; wings not notched. Eyes rougher than in fa males but not glossy as in Nfa-g; heterozygotes Nfa-3/Nfa-g are rough, not glossy (Welshons). intermediate allele not temperature-sensitive dosage compensated

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Synergistic interactions with dx alleles.

      (Gorman and Girton, 1992)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Not rescued by

      Nfa-3 is not rescued by NmMGIIa

      (Ramos et al., 1989)
      Comments

      The P{MGIIa} construct fails to rescue.

      (Ramos et al., 1989)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Welshons.

      Arose on: Nunspecified, an allele of the 'nd' class.

      Comments
      Comments

      Nfa-3 appears to act cell autonomously.

      (Markopoulou and Artavanis-Tsakonas, 1991)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      References (7)