FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\cacH18
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General Information
Symbol
Dmel\cacH18
Species
D. melanogaster
Name
FlyBase ID
FBal0012907
Feature type
allele
Associated gene
Dmel\cac
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description

Amino acid replacement: W?term.

(Smith et al., 1998)

The single transition occurs near the 3' end of exonI/IIa. This change would cause premature termination and eliminate expression of isoforms containing the relatively unconserved amino acid sequence encoded by exon I/IIa.

(Smith et al., 1998)

Nucleotide substitution: G?A.

(Smith et al., 1998)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:11,975,760..11,975,760 [-]
Nucleotide change:

G11975760A

Reported nucleotide change:

G?A

Amino acid change:

W348term | cac-PA; W348term | cac-PB; W348term | cac-PE; W348term | cac-PH; W348term | cac-PI; W348term | cac-PL; W348term | cac-PM; W454term | cac-PN; W348term | cac-PO; W348term | cac-PP

Reported amino acid change:

W?term

Comment:

TGG to TAG; mutation falls within one of the alternative ninth cac exons and therefore only effects some protein isoforms.

(Smith et al., 1998)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      cacH18 mutant males, but not females, show a more severe age-dependent decline in locomotion, as compared to controls; females, but not males, also show a significantly decreased lifespan, as compared to controls.

      cacH18 mutants show decreased cardiac function, as shown by the significant decrease in heart rate, but not in fractional shortening, end diastolic diameter, end systolic diameter or arrhythmic index, as compared to controls.

      (Lam et al., 2018)

      cacH18/Df(1)RC29 females do not show convulsion phenotypes when exposed to 37oC.

      (Peixoto and Hall, 1998)

      Phenotype restricted to the visual system. General characteristics of mutant phenotype: Song pulse - wild-type; Optomotor test - mutant; CC-phototaxis - mutant; Y-phototaxis - mutant; ERG transients - mutant; ERG LCRP amplitude - mutant; ERG LCRP kinetics - wild-type; ERG Rebound - slightly affected; ERG refractory wandering - wild-type.

      (Smith et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      cacH18 is a suppressor of abnormal neurophysiology phenotype of Ihf03355

      (Hu et al., 2015)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      Extensive phenogenetic analysis of allelic combinations reveals a phenotypic series for visually mediated behaviors and genetically separable ERG defects and courtship song defects.

      (Smith et al., 1998)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Heisenberg.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      CacH18
      (Hu et al., 2015)
      cacH18
      (Huang et al., 2025, Hidalgo et al., 2021, Lam et al., 2018, Tong et al., 2016)
      nbA1
      nbAH18
      (Hall and Xu, 2005, Bulthoff, 1982)
      opm18
      Name Synonyms
      Secondary FlyBase IDs
        References (10)