FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ndl5
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General Information
Symbol
Dmel\ndl5
Species
D. melanogaster
Name
FlyBase ID
FBal0012925
Feature type
allele
Associated gene
Dmel\ndl
Associated Insertion(s)
Carried in Construct
Also Known As
ndl169
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous ndl5 follicle cell clones are produced via Scer\GAL4e22c-mediated expression of FLP recombinase. In some egg chambers all follicle cells appear to be mutant, indcating that ndl5 mutants do not confer any defect in viability or growth.

      Ventral follicle cells homozygous for the class I ndl5 allele do not perturb dorso-ventral patterning in the progeny embryos.

      (Stein et al., 2008)

      Class I allele. Affected embryos show early developmental arrest, failing to reach the cellular blastoderm stage. Eggs are very fragile, showing an "oozy eggshell" phenotype.

      (Hong and Hashimoto, 1996)

      Embryos derived from homozygous females are dorsalised.

      (Carroll et al., 1987)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Double mutant combinations with eaD1 are strongly dorsalizing.

      (Chasan et al., 1992)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Class I allele.

      (LeMosy et al., 2000)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      References (6)