FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ninaA1
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General Information
Symbol
Dmel\ninaA1
Species
D. melanogaster
Name
FlyBase ID
FBal0012959
Feature type
allele
Associated gene
Dmel\ninaA
Associated Insertion(s)
Carried in Construct
Also Known As
ninaAP228
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Schneuwly et al., 1989)
Progenitor genotype
Cytology
Description

Nucleotide substitution: G1128A.

(Schneuwly et al., 1989)

Amino acid replacement: W208term.

(Schneuwly et al., 1989)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:878,083..878,083 [+]
Nucleotide change:

G878083A

Reported nucleotide change:

G895A

Amino acid change:

W208term | ninaA-PA

Reported amino acid change:

W208term

Comment:

TGG to TGA

(Schneuwly et al., 1989, Shieh et al., 1989)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      photoreceptor cell & endoplasmic reticulum

      (Colley et al., 1991)
      Detailed Description
      Statement
      Reference

      ERG recordings from ninaA1 homozygous mutant clones in the eye do not show a prolonged depolarization afterpotential (PDA) after exposure to light, unlike wild type.

      (Huang et al., 2015)

      Displays locomotor activity rhythm with an approximately 24h period.

      (Vosshall and Young, 1995)

      Temperature sensitive (restrictive temperature: 29oC, permissive temperature: 18oC). At the restrictive temperature most of the Rh1 opsin in the photoreceptor cells R1-R6 is in the ER. These cells also show large accumulations of ER at the restrictive temperature.

      (Colley et al., 1991)

      Dramatic reductions in rhodopsin levels of R1--R6 cells with concomitant impaired visual function.

      (Stamnes et al., 1991)

      With respect to defective PDA, ninaA2 > ninaA1 > ninaA3.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      ninaA1/ninaA[+] is a suppressor of increased cell death phenotype of p53UAS.cJa

      (Mendes et al., 2009)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      ninaA1/ninaA[+] is a suppressor of outer photoreceptor cell phenotype of p53UAS.cJa

      (Mendes et al., 2009)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Loss of one genomic copy of ninaA, in a ninaA1/+ heterozygous background, protects the outer photoreceptor cells from Scer\GAL4ninaE.PT;p53Scer\UAS.cJa-induced apoptosis.

      (Mendes et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      The phenotype can be fully rescued by P element mediated introduction of a wild type copy of ninaA.

      (Stamnes et al., 1991)
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      Pak.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      References (11)