FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ninaE9
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General Information
Symbol
Dmel\ninaE9
Species
D. melanogaster
Name
FlyBase ID
FBal0013014
Feature type
allele
Associated gene
Dmel\ninaE
Associated Insertion(s)
Carried in Construct
Also Known As
ninaEP352
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Lindsley and Zimm, 1992)
Progenitor genotype
Cytology
Description

FlyBase curator comment: Molecular modification data for this allele is ambiguous. Has been variously reported as Q251term (FBrf0050132 and FBrf0066905), G314E (FBrf0080181) and G314term (FBrf0085395).

(Kumar and Ready, 1995, Kurada and O'Tousa, 1995, Washburn and O'Tousa, 1989)

Amino acid replacement: ?314term.

(Kumar and Ready, 1995)

Amino acid replacement: G314E.

(Kurada and O'Tousa, 1995)

ca 10-6 normal RH1 level. Amino acid replacement: Q251. Same nonsense mutation and polymorphisms as ninaE1. FlyBase curator comment: Molecular modification data for this allele is ambiguous. Has been variously reported as Q251 (FBrf0050132 and FBrf0066905), G314E (FBrf0080181) and G314@ (FBrf0085395).

(Lindsley and Zimm, 1992)

Amino acid replacement: Q251term.

(Washburn and O'Tousa, 1989)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:19,886,794..19,886,794 [-]
Nucleotide change:

G19886794A

Amino acid change:

G314E | ninaE-PA

Reported amino acid change:

G314E|FBrf0080181

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change in FBrf0080181; there are conflicting reports on the amino acid change in this allele; see the FlyBase ninaE9 allele report

(Kurada and O'Tousa, 1995)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant larvae show defects in discrimination between 18[o]C and 24[o]C in a binary choice thermotaxis assay compared to controls, but discrimination between 18[o]C and cooler or very warm temperatures is normal.

      (Shen et al., 2011)

      Individuals exhibit cytoplasmic curtains of rhabdomere membrane, rhabdomeres have degenerated.

      (Kumar and Ready, 1995)

      Mean number of R1-6 rhabdomere/ommatidium decreased as rapidly as for ninaE17.

      (Leonard et al., 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      ninaE9 is a suppressor of phenotype of norpAP24

      (Kurada and O'Tousa, 1995)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Pak.

      (Lindsley and Zimm, 1992)
      Comments
      Comments

      Encodes 1.6x10-4% of wild type levels of R1-6 rhodopsin (Johnson and Pak, J. Gen Physiol. 88:651--673 ).

      (Leonard et al., 1992)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      References (10)