FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\norpAH43
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General Information
Symbol
Dmel\norpAH43
Species
D. melanogaster
Name
FlyBase ID
FBal0013122
Feature type
allele
Associated gene
Dmel\norpA
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Yoon et al., 2004)
Progenitor genotype
Cytology
Description

Amino acid replacement: S347N.

(Yoon et al., 2004)

Amino acid replacement: T1007S.

(Yoon et al., 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      A receptor potential of 12.5 mV peak amplitude (40% of wild-type amplitude) and 6.5 mV steady-state amplitude can be elicited (measured by intracellular recording) in norpA29 mutants by a bright 10 second white stimulus.

      (Leung et al., 2008)

      The ERG is abnormal. Flies show cell degeneration in the lamina monopolar cell layer and the cortex of the optic lobe, although the retina appears normal.

      (Isono et al., 1981)

      intermediate ERG

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      In the norpA29 inaEN125 double mutant, intracellular recording of the receptor potential shows that a receptor potential of 11.5mV peak amplitude is generated in response to a bright 10 second white stimulus, but it rises to a peak within 0.1 seconds and rapidly and completely decays to baseline within 0.25 seconds.

      No receptor potential (measured by intracellular recording) can be elicited in norpA29 inaExl18 double mutants.

      (Leung et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Heisenberg.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      norpA29
      norpAH43
      (Leung et al., 2008, Yoon et al., 2004)
      rofH43
      (Isono et al., 1981)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)