FB2026_02 , released June 18, 2026
Allele: Dmel\norpAH52
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General Information
Symbol
Dmel\norpAH52
Species
D. melanogaster
Name
FlyBase ID
FBal0013124
Feature type
allele
Associated gene
Dmel\norpA
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: S551Y.

    (Matsumoto et al., 1994)

    Nucleotide substitution: C2304A. Amino acid replacement: S551Y.

    (Masai and Hotta, 1991)

    Ser551 --> Tyr

    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    X:4,358,815..4,358,815 [+]
    Nucleotide change:

    C4358815A

    Reported nucleotide change:

    C2304A

    Amino acid change:

    S551Y | norpA-PA; S551Y | norpA-PB; S551Y | norpA-PC; S551Y | norpA-PD; S551Y | norpA-PE; S551Y | norpA-PF

    Reported amino acid change:

    S551Y

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    (Matsumoto et al., 1994, Masai and Hotta, 1991)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        In larvae with the temperature-sensitive norpA31 allele reared at the permissive temperature (25[o]C), thermal preference is indistinguishable from wild-type, whereas after a 37[o]C heat shock the larvae lost their ability to choose 18[o]C.

        (Kwon et al., 2008)

        The amplitude of quantum bumps in mutant photoreceptors is smaller than wild type (when ATP is present in the intracellular solution during recordings).

        (Hardie et al., 2002)

        The size and shape of the quantum bumps are unaffected, although the latency is significantly different from wild type.

        (Scott and Zuker, 1998)

        Photoreceptors degenerate with age. Photoreceptor potential disappears within less than 1 second with a temperature shift to nonpermissive temperatures.

        (Matsumoto et al., 1994)

        Temperature-sensitive mutation.

        (Masai and Hotta, 1991)

        temperature-sensitive allele

        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer

        Heisenberg.

        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        References (12)