FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ort5
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General Information
Symbol
Dmel\ort5
Species
D. melanogaster
Name
FlyBase ID
FBal0013288
Feature type
allele
Associated gene
Dmel\ort
Associated Insertion(s)
Carried in Construct
Also Known As
ortUS6096
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Nucleotides +359 to +361 in the coding region are substituted by the two nucleotides AG, resulting in a frameshift.

    (Gengs et al., 2002)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    delins
    3R:19,662,008..19,662,010 [+]
    Inserted_sequence:

    AG

    Comment:

    The three nucleotides CCA at postion 259-361 in the CDS are replaced by the sequence AG resulting in a frame shift at amino acid 120.

    (Gengs et al., 2002)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Compared with wild-type, ort5 mutants show moderate reduction in the 1F1 component of frequency-tagged steady-state visually evoked potentials. 2F1 responses are almost completely eliminated in the mutant flies. The 2F1 response in ort5 mutants is only evident at high contrast, where it is approximately 20% of the wild-type, though significantly above the system noise. The fourth-order intermodulation term 2F1+2F2 is entirely abolished in the mutant, with the level of signal similar to the system noise.

        (Afsari et al., 2014)

        The depolarizing "on" and "off" transients that are normally seen in the electroretinograms of wild type flies are absent in ort5 mutant flies, even at saturating light intensities.

        (Pantazis et al., 2008)

        Mutant larvae and adults show increased susceptibility to abamectin or ivermectin compared to wild type (viability is reduced). They do not show any increased sensitivity to ethanol compared to wild type. ort5/Df(3R)12 adults and ortP364/ort5 show increased susceptibility to abamectin compared to wild type (viability is reduced). Mutant adults do not show increased sensitivity to dieldrin compared to wild type.

        (Georgiev et al., 2002)

        Rhabdomeres of young flies are reduced in size and show aberrant packing of microvilli. Rhabdomeres are nearly wild type in adults.

        (O'Tousa et al., 1989)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (2)
        Notes on Origin
        Discoverer

        Hardy, Orevi and Merriam.

        (Lindsley and Zimm, 1992)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        References (8)