FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\pb11
Open Close
General Information
Symbol
Dmel\pb11
Species
D. melanogaster
Name
FlyBase ID
FBal0013515
Feature type
allele
Associated gene
Dmel\pb
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Cribbs et al., 1992)
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology

Polytene chromosomes normal.

Description

Amino acid replacement: L223F.

(Tayyab et al., 2004)

Nucleotide substitution: A669T.

(Tayyab et al., 2004)

The nucleotide substitution A669T results in the L223F amino acid replacement. The mutant allele also contains the nucleotide polymorphism C2102A, which results in a P701H protein polymorphism (coordinates of the lesions are the position in the 2-μ-4a spliced form of pb).

(Tayyab et al., 2004)

Amino acid replacement: P701H.

(Tayyab et al., 2004)

Nucleotide substitution: C2102A.

(Tayyab et al., 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:6,711,847..6,711,847 [-]
Nucleotide change:

A6711847T

Reported nucleotide change:

A669T

Amino acid change:

L223F | pb-PA; L218F | pb-PB; L218F | pb-PC; L213F | pb-PD

Reported amino acid change:

L223F

Comment:

A polymorphism (P701H) is also seen in this strain. Reported coordinates are with respect to pb-RA and pb-PA.

(Tayyab et al., 2004)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      pb11/pb20 flies have a hypomorphic phenotype; the maxillary palps are reduced, the proboscis is transformed into aristae, and the number of pseudotracheal rows is reduced to two to three.

      (Tayyab et al., 2004)

      The labial palp is transformed to antenna.

      (Cribbs et al., 1992)

      antenna

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Cain.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      c13
      (Cribbs et al., 1992)
      pb11
      (Tayyab et al., 2004)
      pbc13
      Name Synonyms
      Secondary FlyBase IDs
        References (2)