FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\pb14
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General Information
Symbol
Dmel\pb14
Species
D. melanogaster
Name
FlyBase ID
FBal0013518
Feature type
allele
Associated gene
Dmel\pb
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology

Polytene chromosomes normal.

Description

Amino acid replacement: S335P.

(Tayyab et al., 2004)

Nucleotide substitution: T1003C.

(Tayyab et al., 2004)

Nucleotide substitution: C1095T.

(Tayyab et al., 2004)

Amino acid replacement: Q484term.

(Tayyab et al., 2004)

Nucleotide substitution: T1344C.

(Tayyab et al., 2004)

The nucleotide substitution T1003C results in the amino acid replacement S335P, and the nucleotide substitution C1450T results in a premature stop codon at residue 484. The mutant allele also contains the nucleotide polymorphism G1964C, which results in a C655S protein polymorphism and the silent nucleotide polymorphisms C1095T and T1344C (coordinates of the lesions are the position in the 2-μ-4a spliced form of pb).

(Tayyab et al., 2004)

Nucleotide substitution: C1450T.

(Tayyab et al., 2004)

Nucleotide substitution: G1964C.

(Tayyab et al., 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:6,710,067..6,710,067 [-]
Nucleotide change:

C6710067T

Reported nucleotide change:

C1450T

Amino acid change:

Q484term | pb-PA; Q479term | pb-PB; Q479term | pb-PC; Q474term | pb-PD

Reported amino acid change:

Q484term

Comment:

Reported coordinates are with respect to pb-RA and pb-PA.

(Tayyab et al., 2004)
point_mutation
3R:6,710,741..6,710,741 [-]
Nucleotide change:

T6710741C

Reported nucleotide change:

T1003C

Amino acid change:

S335P | pb-PA; S330P | pb-PB; S330P | pb-PC; S325P | pb-PD

Reported amino acid change:

S335P

(Tayyab et al., 2004)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      pb14/pb20 flies have vestigial maxillary palps, the labellar caps are fully transformed to tarsi and the pseudotracheae are missing.

      (Tayyab et al., 2004)

      The labial palp is transformed to antenna at 29oC and prothoracic leg at 22oC.

      (Cribbs et al., 1992)

      18oC --> antenna 29oC --> leg

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Other
      Statement
      Reference

      ctL188, pb14 has pseudotrachea phenotype

      (Johnston et al., 1998)

      ctL188, pb14 has labellum phenotype

      (Johnston et al., 1998)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Fornili.

      Induced on: pp.

      (Johnston et al., 1998)
      Comments
      Comments

      Behaves as a hypomorph at 29oC and an amorph at 22oC.

      (Cribbs et al., 1992)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      f73
      (Cribbs et al., 1992)
      pb14
      (Tayyab et al., 2004)
      pbf73
      Name Synonyms
      Secondary FlyBase IDs
        References (3)