FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\pnt1
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General Information
Symbol
Dmel\pnt1
Species
D. melanogaster
Name
FlyBase ID
FBal0013910
Feature type
allele
Associated gene
Dmel\pnt
Associated Insertion(s)
Carried in Construct
Also Known As
pnt8B74, pointed8B74, pnt8B
Key Links
Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Gabay et al., 1996)

loss of function allele

(Klambt, 1993)
Mutagen
ethyl methanesulfonate
(Scholz et al., 1993, Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Malpighian tubule elongation is incomplete in homozygous embryos.

      (Harbecke and Lengyel, 1995)

      Tracheal dorsal trunks fail to form in the embryo, due to failure in migration of trachea cells. Embryonic muscles 4, 11, 19 and 20 are absent and muscles 15, 16 and 17 are small and displaced (though note that the ventral epidermis is affected in pnt mutants). Commissures in the CNS are fused.

      (Klambt, 1993)

      CNS and tracheal phenotype.

      (Scholz et al., 1993)

      embryonic lethal. Zygotic expression in embryo. Head skeleton of embryo pointed; median part of all denticle bands deleted. CNS broad and less dense than wild type. Sensory organs (maxillary, antennal and Keilin's organs) spread.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Less than 50% of wild type number of ventral epidermal cells expressing P{lacZ}BP28 are evident in mutant embryos. oc expression is greatly reduced along the midline.

      (Kim and Crews, 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      References (16)