FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\rdgB5
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General Information
Symbol
Dmel\rdgB5
Species
D. melanogaster
Name
FlyBase ID
FBal0014482
Feature type
allele
Associated gene
Dmel\rdgB
Associated Insertion(s)
Carried in Construct
Also Known As
rdgBEE170
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutants exhibit a light dependant retinal degeneration phenotype. This is characterised by the loss of outer R1-R6 photoreceptor cell rhabdomeres as well as photoreceptor cell vacularization.

      (Alloway et al., 2000)

      Severe and rapid retinal degradation in the light.

      (Colley et al., 1995)

      Photoreceptors R1 to R6 show cellular degeneration and reduced concentrations of photoreceptor proteins 11 days after exposure to a light flash.

      (Smith et al., 1991)

      The retina appears fairly normal in newly emerged flies but degenerates with age, particularly the R1-R6 receptors. The lamina is striated into neat cartridges in the newly emerged fly, but appears degenerate and disorganised in older flies. The medulla appears relatively normal at all ages from newly emerged to 3 week old flies. R1-R6 photopigment levels are one-third to one-half of normal in newly emerged flies, and decline within a week to undetectable levels.

      (Stark et al., 1983)

      Photoreceptors R7 and R8 are preserved in less than 10% of ommatidia in 7 day old mutant flies. The electroretinogram (ERG) of 7 day old flies shows reduced receptor potentials.

      (Harris and Stark, 1977)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      rdgB5 has increased cell death phenotype, suppressible by BacA\p35GMR.PH

      (Hsu et al., 2004)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      rdgB5 has retina phenotype, suppressible by BacA\p35GMR.PH

      (Hsu et al., 2004)

      rdgB5 has photoreceptor cell R5 phenotype, suppressible by Arr25

      (Alloway et al., 2000)

      rdgB5 has photoreceptor cell R6 phenotype, suppressible by Arr25

      (Alloway et al., 2000)

      rdgB5 has photoreceptor neuron phenotype, suppressible by Arr25

      (Alloway et al., 2000)

      rdgB5 has retina phenotype, suppressible by Arr25

      (Alloway et al., 2000)

      rdgB5 has photoreceptor cell R1 phenotype, suppressible by Arr25

      (Alloway et al., 2000)

      rdgB5 has photoreceptor cell R2 phenotype, suppressible by Arr25

      (Alloway et al., 2000)

      rdgB5 has photoreceptor cell R3 phenotype, suppressible by Arr25

      (Alloway et al., 2000)

      rdgB5 has photoreceptor cell R4 phenotype, suppressible by Arr25

      (Alloway et al., 2000)

      rdgB5 has photoreceptor cell R1 phenotype, suppressible by inaC2

      (Smith et al., 1991)

      rdgB5 has photoreceptor cell R2 phenotype, suppressible by inaC2

      (Smith et al., 1991)

      rdgB5 has photoreceptor cell R3 phenotype, suppressible by inaC2

      (Smith et al., 1991)

      rdgB5 has photoreceptor cell R4 phenotype, suppressible by inaC2

      (Smith et al., 1991)

      rdgB5 has photoreceptor cell R5 phenotype, suppressible by inaC2

      (Smith et al., 1991)

      rdgB5 has photoreceptor cell R6 phenotype, suppressible by inaC2

      (Smith et al., 1991)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The a light dependant retinal degeneration phenotype is partially rescued by Arr25.

      (Alloway et al., 2000)

      rdgB5 inaC2 photoreceptors are morphologically indistinguishable from wild-type 11 days after exposure to a light flash.

      (Smith et al., 1991)
      Xenogenetic Interactions
      Statement
      Reference

      Expression of BacA\p35GMR.PH delays the degeneration of the retina in rdgB5 flies, but does not prevent it.

      (Hsu et al., 2004)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Alleles can be ranked with respect to how much R7 and R8 are affected in each mutant; rdgB5 > rdgB7 > rdgB6 = rdgB8 > rdgB1 = rdgB9.

      (Harris and Stark, 1977)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      rdgB5
      (Hsu et al., 2004)
      rdgBEE170
      (Alloway et al., 2000, Shieh and Zhu, 1996, Colley et al., 1995, Smith et al., 1991, Stark et al., 1983, Harris and Stark, 1977)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)