Embryos derived from females homozygous or hemizygous for Cks30A^HG24 arrest development at the onset of embryogenesis, typically with a single metaphase mitotic spindle. Some embryos progress through a limited number of divisions before arresting, again in a metaphase-like state. These metaphase-arrested spindles are zygotic and not derived from the female meiotic spindle. In Cks30A^HG24 mutants, the first events of female meiosis are unaffected. The karyosome appears normal, and the timing of nuclear envelope breakdown and the appearance of the spindle is also unaffected in the majority of mutant ovaries, although approximately 7% have abnormal spindles and fail chromosome congression on the spindle. Consistent meiotic defects were detected upon ovulation and entry into the second meiotic division. Rotation of the spindle fails in the majority of oocytes, and assembly of the meiosis II spindle is abnormal. The most common defect in Cks30A^HG24 mutants is a kink and/or separation of the two tandem spindles. In more severe cases, the meiotic spindle breaks down and chromosome segregation is severely disrupted. Despite these errors, the female meiotic products appear to exit meiosis, reforming nuclear envelopes, and pronuclear fusion occurs. After completion of meiosis, the polar body microtubule aster does not form in Cks30A^HG24 mutants, instead a shell of microtubules surrounds the chromatin. Cks30A^HG24 and Cks30A^RA74/Cks30A^HG24 mutants exhibit defects in abdominal cuticle deposition, indicative of a partial disruption of larval abdominal histoblast development.

Embryos derived from homozygous females show embryonic development and form fragmented cuticle.