FlyBase Allele Report: Dmel\rn[roe-3]

General Information

Symbol

Dmel\rn^roe-3

Species

D. melanogaster

Name

FlyBase ID

FBal0014645

Feature type

allele

Associated gene

Dmel\rn

Associated Insertion(s)

Carried in Construct

Also Known As

roe³

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

Progenitor genotype

Cytology

Description

Coordinates according to accession number AF395904. Mutation in the "roe" specific exon of rn.

(St Pierre et al., 2002)

Nucleotide substitution: C629T.

(St Pierre et al., 2002)

Amino acid replacement: Q191term.

(St Pierre et al., 2002)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:7,276,851..7,276,851 [-]

Nucleotide change:

C7276851T

Reported nucleotide change:

C629T

Amino acid change:

Q190term | rn-PC

Reported amino acid change:

Q191term

(St Pierre et al., 2002)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Ma et al., 1996, Cavener et al., 1986)

visible | recessive

(Lewis et al., 1980)

Phenotype Manifest In

eye

(Ma et al., 1996, Cavener et al., 1986, Lewis et al., 1980)

ommatidium

(Cavener et al., 1986)

Detailed Description

Statement

Reference

rn^roe-1/rn^roe-3 adult eyes show a mild small and rough eye phenotype.

rn¹⁶/rn^roe-3 adult eyes show a moderate small and rough eye phenotype.

(Melicharek et al., 2008)

rn^roe-3 shows "roe" phenotypes.

(St Pierre et al., 2002)

Homozygotes exhibit a small rough eye phenotype.

(Ma et al., 1996)

Rough eye: irregular facets. Acts in dosage sensitive manner.

(Cavener et al., 1986)

Rough eye phenotype.

(Lewis et al., 1980)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

rn^roe-3 is an enhancer of phenotype of gl³

(Ma et al., 1996)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

rn^KM29

(Melicharek et al., 2008)

rn^KK16

(Melicharek et al., 2008)

rn^BM10

(Melicharek et al., 2008)

rn^SM8

(Melicharek et al., 2008)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

7411

w¹¹¹⁸; rn^roe-3 p^p cu¹/TM3, P{ftz-lacZ.ry⁺}TM3, Sb¹ ry^*

Notes on Origin

Discoverer

Grigliatti.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

rn^roe-3

roe³

(Melicharek et al., 2008, St Pierre et al., 2002, Ma et al., 1996, Cavener et al., 1986)

roe^5.15

(Lewis et al., 1980)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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