FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Polr2A3
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General Information
Symbol
Dmel\Polr2A3
Species
D. melanogaster
Name
FlyBase ID
FBal0014660
Feature type
allele
Associated gene
Dmel\Polr2A
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Voelker et al., 1985)
Progenitor genotype
Polr2A4
(Voelker et al., 1985)
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Haplospecific lethal. Survives, at least with a low frequency, as a homozygote, but is lethal in hemizygotes.

      (Lindsley and Zimm, 1992)

      Mutant flies show resistance to α-amanitin.

      (Voelker et al., 1985)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      RpII215[+]/Polr2A3 is an enhancer of wing vein | ectopic phenotype of Snr1E1

      (Marenda et al., 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Marcal1del/Marcal1del RpII2153/+ embryos show a reduced hatching rate compared to controls at 20[o]C.

      (Baradaran-Heravi et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      A11
      (Voelker et al., 1985)
      Polr2A3
      RpII2153
      (Baradaran-Heravi et al., 2012, Popodi et al., 2010-)
      RpII215A11
      (Lindsley and Zimm, 1992)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)