FlyBase Allele Report: Dmel\Polr2A[8]

General Information

Symbol

Dmel\Polr2A⁸

Species

D. melanogaster

Name

FlyBase ID

FBal0014665

Feature type

allele

Associated gene

Dmel\Polr2A

Associated Insertion(s)

Carried in Construct

Also Known As

C20

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Chen et al., 1993, Voelker et al., 1985)

Progenitor genotype

Polr2A⁴

(Chen et al., 1993, Voelker et al., 1985, Mortin and Kaufman, 1982)

Cytology

Description

Amino acid replacement: L878F. Nucleotide substitution: C4447T.

(Chen et al., 1993)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:11,566,672..11,566,672 [-]

Nucleotide change:

C11566672T

Reported nucleotide change:

C4447T

Amino acid change:

L878F | Polr2A-PA

Reported amino acid change:

L878F

(Chen et al., 1993)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

chemical resistant

(Voelker et al., 1985)

lethal | recessive | heat sensitive

(Krasnoselskaya et al., 1998, Lindsley and Zimm, 1992, Voelker et al., 1985)

viable

(Chen et al., 1993)

Phenotype Manifest In

capitellum

(Chen et al., 1993)

Detailed Description

Statement

Reference

Exhibits the Ubx effect: heterozygotes partially transform the capitellum of the haltere into the wing blade.

(Chen et al., 1993)

Haplospecific lethal. Survives, at least with a low frequency, as a homozygote, but is lethal in hemizygotes.

(Lindsley and Zimm, 1992)

Mutant flies show resistance to α-amanitin.

(Voelker et al., 1985)

Temperature-sensitive mutation.

(Mortin and Kaufman, 1982)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Marcal1^del, RpII215[+]/Polr2A⁸ has partially lethal - majority die | embryonic stage phenotype

(Baradaran-Heravi et al., 2012)

Phenotype Manifest In

Enhancer of

Statement

Reference

RpII215[+]/Polr2A⁸ is an enhancer of wing vein | ectopic phenotype of Snr1^E1

(Marenda et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Marcal1^del/Marcal1^del RpII215⁸/+ embryos show a reduced hatching rate compared to controls at 20[o]C.

(Baradaran-Heravi et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

3660

v¹ Polr2A⁸/FM7a/Dp(1;Y)y⁺v⁺#3

Kyoto

107163

v¹ Polr2A⁸/FM7a/Dp(1;Y)y⁺v⁺#3

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

C20

(Chen et al., 1993, Voelker et al., 1985)

Polr2A⁸

RpII215⁸

(Baradaran-Heravi et al., 2012, Popodi et al., 2010-)

RpII215^C20

(Lindsley and Zimm, 1992)

RpII^C20

(Mortin and Kaufman, 1982)

Ubl^C20

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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