FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\run25
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General Information
Symbol
Dmel\run25
Species
D. melanogaster
Name
FlyBase ID
FBal0014870
Feature type
allele
Associated gene
Dmel\run
Associated Insertion(s)
Carried in Construct
Also Known As
runYC
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Bernstein and Cline, 1994, Lindsley and Zimm, 1992, Torres and Sanchez, 1992)
Mutagen
ethyl methanesulfonate
(Lindsley and Zimm, 1992, Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Wieschaus.

      (Lindsley and Zimm, 1992)
      Comments
      Comments

      The expression of l(1)sc is altered during stage 9 in homozygous mutant embryos.

      (Martin-Bermudo et al., 1991)

      Used as assay for early dosage compensation in Sxl hypomorphic mutants. Males do not express Sxl, predicting that run25 should have the same phenotype in males irrespective of which loss of function Sxl allele they carry. However the distribution of run25 mutant phenotypes in males varies indicating it is sensitive to genetic background.

      (Bernstein and Cline, 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      l(1)YC28
      (Lindsley and Zimm, 1992)
      run25
      runYC28
      (Torres and Sanchez, 1992)
      runYC
      (Harbecke and Lengyel, 1995, Martin-Bermudo et al., 1991, Tearle and Nusslein-Volhard, 1987)
      runtYC
      (Macias et al., 1994)
      Name Synonyms
      Secondary FlyBase IDs
        References (10)