FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\S2
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General Information
Symbol
Dmel\S2
Species
D. melanogaster
Name
FlyBase ID
FBal0015109
Feature type
allele
Associated gene
Dmel\S
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
Progenitor genotype
Cytology

Polytene chromosomes normal.

(Lewis, 1945)
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygous S2 mutants show R7 photoreceptor loss.

      (Murillo-Maldonado et al., 2011)

      Like S1. RK1A.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      Statement
      Reference

      S2 has decreased cell number | adult stage | dominant phenotype, non-enhanceable by sl2

      (Murillo-Maldonado et al., 2011)
      Enhancer of
      Statement
      Reference

      S[+]/S2 is an enhancer of abnormal size | adult stage phenotype of sl2

      (Murillo-Maldonado et al., 2011)
      Phenotype Manifest In
      NOT Enhanced by
      Statement
      Reference

      S2 has photoreceptor cell R7 | adult stage phenotype, non-enhanceable by sl2

      (Murillo-Maldonado et al., 2011)
      Enhancer of
      Statement
      Reference

      S[+]/S2 is an enhancer of wing blade phenotype of sl2

      (Murillo-Maldonado et al., 2011)

      S[+]/S2 is an enhancer of wing vein | ectopic phenotype of sl2

      (Murillo-Maldonado et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      One copy of S2 enhances the reduction in wing blade area seen in homozygous sl2 males.

      One copy of S2 significantly enhances the ectopic wing vein phenotype seen in sl2 homozygotes.

      sl2 does not enhance the dominant R7 photoreceptor loss seen in S2 heterozygotes.

      (Murillo-Maldonado et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (10)
      Notes on Origin
      Discoverer

      Redfield, Nov. 1925.

      Arose on: In(2L)Cy.

      Associated with: In(2L)t.

      (Lewis, 1945)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      S2
      (Murillo-Maldonado et al., 2011)
      SR
      Name Synonyms
      Secondary FlyBase IDs
        References (4)