FB2026_02 , released June 18, 2026
Allele: Dmel\Scr3
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General Information
Symbol
Dmel\Scr3
Species
D. melanogaster
Name
FlyBase ID
FBal0015279
Feature type
allele
Associated gene
Dmel\Scr
Associated Insertion(s)
Carried in Construct
Also Known As
EdR18, Scrr18
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Sivanantharajah and Percival-Smith, 2009, Pattatucci et al., 1991)
Mutagen
ethyl methanesulfonate
(Pattatucci et al., 1991, Lewis et al., 1980, Lewis et al., 1980)
Progenitor genotype
Cytology

Polytene chromosomes normal.

(Pattatucci et al., 1991)
Description

Amino acid replacement: P306L.

(Sivanantharajah and Percival-Smith, 2009)

Nucleotide substitution: C917T.

(Sivanantharajah and Percival-Smith, 2009)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:6,841,264..6,841,264 [-]
Nucleotide change:

C6841264T

Reported nucleotide change:

C917T

Amino acid change:

P306L | Scr-PA; P306L | Scr-PB; P306L | Scr-PD; P306L | Scr-PE; P306L | Scr-PF

Reported amino acid change:

P306L

(Sivanantharajah and Percival-Smith, 2009)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygous and Scr3/Df(3R)WIN3 males have a reduction in the number of sex comb bristles on the prothoracic leg compared to wild-type males.

      Scr3/Df(3R)WIN3 and Scr3/Scr13A flies have a reduced number of rows of pseudotrachea on the proboscis compared to controls.

      Scr3/Df(3R)WIN3 larvae have a reduced number of nuclei in the salivary gland compared to controls.

      (Sivanantharajah and Percival-Smith, 2009)

      Prothoracic to mesothoracic, pronotal to mesonotal and labial to maxillary transformations. Polyphasic semi-lethality.

      (Pattatucci et al., 1991)

      Semilethal. Surviving heterozygotes with Scr1 or Df(3R)Scr are characterised by a severe reduction in number and sometimes absence of sex comb teeth. The teeth present are often thin and weakly pigmented. An additional transformation is seen in heterozygotes with Df(3R)Scr, labial palps are transformed to maxillary palps with reduction in the number of pseudotracheal rows.

      (Lewis et al., 1980)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      R. Lewis.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      EdR18
      (Lewis et al., 1980, Lewis et al., 1980)
      Scr3
      (Sivanantharajah and Percival-Smith, 2009)
      Scrr18
      (Pattatucci et al., 1991, Hazelrigg and Kaufman, 1983)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)