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General Information
Symbol
Dmel\Sh6
Species
D. melanogaster
Name
FlyBase ID
FBal0015546
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Sh101
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Sh6 flies treated with sodium valproate (NaVP) show a reduction in body weight, as is seen in wild-type flies. Treatment of Sh6 flies with NaVP causes an increase in mortality as is seen in wild-type flies.

Flies are significantly more sensitive to acrolein than wild-type flies.

Normal electroretinogram.

abnormal leg shaking under ether anesthesia

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement
Reference
Phenotype Manifest In
Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Fluunspecified Sh6 double heterozygotes hop and fly poorly compared to either single heterozygote at 29oC. Fluunspecified Sh6 double heterozygotes walk and climb normally when raised at 22oC up to seven days after eclosion. After this time there is a gradual loss of function of the mesothoracic legs, first noticeable in their lack of use for climbing. Paralysis of the legs is usually accompanied by formation of a black spot, resembling a wound reaction, at the region of the trochanter and the femoral coxal joint.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer

Homyk.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (5)