FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\shd1
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General Information
Symbol
Dmel\shd1
Species
D. melanogaster
Name
FlyBase ID
FBal0015600
Feature type
allele
Associated gene
Dmel\shd
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Petryk et al., 2003, Lindsley and Zimm, 1992, Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Amino acid replacement: ?136term.

(Petryk et al., 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:14,620,040..14,620,040 [+]
Nucleotide change:

C14620040T

Reported nucleotide change:

C?T

Amino acid change:

R136term | shd-PB; R29term | shd-PC; R136term | shd-PD

Reported amino acid change:

?136term

(Petryk et al., 2003)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Early embryonic development of shd1 mutants is normal until approximately stage 14. At stages 15-16, abnormal morphogenetic movements are apparent that involve failure of head involution, defects in dorsal closure, and aberrant gut looping. shd1/shd2; shdScer\UAS.cPa; Scer\GAL4twi.2PE animals survive to be viable adults. Howver, females of this genotype are sterile, with egg chambers that arrest and degenerate at about stage 8-9 of oogenesis. The ecdysteroid profile of 10-14 hour old shd1 homozygous embryos is abnormal, resembling that seen in 4-6 hour old wild-type embryos.

      (Petryk et al., 2003)

      No differentiation of cuticle or head skeleton.

      (Lindsley and Zimm, 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      shd1/shd2 is rescued by shdUAS.cPa/Scer\GAL4arm.PS

      (Petryk et al., 2003)
      Partially rescued by

      shd1/shd2 is partially rescued by Scer\GAL4twi.2PE/shdUAS.cPa

      (Petryk et al., 2003)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      G.Jurgens

      (Petryk et al., 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      shade1
      (Ruan et al., 2024)
      shd1
      shd6J
      (Lindsley and Zimm, 1992, Tearle and Nusslein-Volhard, 1987)
      shdZ320
      (Petryk et al., 2003)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)