FlyBase Allele Report: Dmel\shn[3]

General Information

Symbol

Dmel\shn³

Species

D. melanogaster

Name

FlyBase ID

FBal0015637

Feature type

allele

Associated gene

Dmel\shn

Associated Insertion(s)

Carried in Construct

Also Known As

shn^TD5

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

PM hybrid dysgenesis

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Grieder et al., 1995)

Mutagen

PM hybrid dysgenesis

(Chase and Baker, 1995, Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Feuillette et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic/first instar larval cuticle

(Marty et al., 2000)

Detailed Description

Statement

Reference

Clonal analysis indicates that shn is not required in the germ line for germ cell proliferation.

(Shivdasani and Ingham, 2003)

Homozygous embryos have a prominent dorsal hole in the cuticle.

(Marty et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

shn³/shn[+] is an enhancer of visible | adult stage phenotype of Hsap\MAPT^UAS.cWa, Scer\GAL4^GMR.PF

(Feuillette et al., 2020)

Phenotype Manifest In

Suppressed by

Statement

Reference

shn³ has embryonic/first instar larval cuticle phenotype, suppressible by brk^XH

(Marty et al., 2000)

Enhancer of

Statement

Reference

shn³/shn[+] is an enhancer of eye phenotype of Hsap\MAPT^UAS.cWa, Scer\GAL4^GMR.PF

(Feuillette et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

shn³ brk^XH double mutant embryos are dorsally closed and differentiate dorsal hairs, but have reduced ventral denticle bands. shn³ brk^XH double mutant clones in the wing disc grow to a large size, in contrast to shn³ single mutant clones.

(Marty et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

51289

w^*; P{neoFRT}42D mago³ shn³/CyO

Notes on Origin

Discoverer

Gergen.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

Shn^TD5

(Zhou et al., 2015)

shn³

(Toraason et al., 2024, Ruiz-Losada et al., 2021, Feuillette et al., 2020)

shn^TD35

(Chen and Schupbach, 2006)

shn^TD5,1

(Chase and Baker, 1995)

shn^TD5,2

(Chase and Baker, 1995)

shn^TD5

(Beira et al., 2014, Pyrowolakis et al., 2004, Muller et al., 2003, Shivdasani and Ingham, 2003, Marty et al., 2000, Henderson et al., 1999, Matunis et al., 1997, Riese et al., 1997, Grieder et al., 1995, Tearle and Nusslein-Volhard, 1987)

shnTD5

(Charbonnier et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (18)

Report Sections

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