FlyBase Allele Report: Dmel\sv[spa-Cat]

General Information

Symbol

Dmel\sv^spa-Cat

Species

D. melanogaster

Name

Cataract

FlyBase ID

FBal0015987

Feature type

allele

Associated gene

Dmel\sv

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Belgovsky, 1937)

Progenitor genotype

Caused by aberration

Df(4)Cat

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Hochman, 1971, Davis, 1969, Hochman et al., 1964, Morgan, 1941)

visible | dominant

(Hochman, 1971, Davis, 1969, Hochman et al., 1964, Belgovsky, 1937)

visible | dominant | cold sensitive

(Morgan, 1947, Morgan, 1941)

Phenotype Manifest In

eye

(Morgan, 1941, Belgovsky, 1937)

eye | posterior

(Belgovsky, 1937)

Detailed Description

Statement

Reference

Roughness and thickening of the posterior part of the eye.

(Morgan, 1947)

In heterozygotes the posterior third of the eye is rough, facets are confused. Female homozygotes exhibit bulging eye surface that is rough and sparkling. This phenotype is suppressed by the presence of the Y chromosome (XY or XXY individuals).

(Morgan, 1941)

Heterozygotes have good viability and fertility. Eyes are rough, mostly only on the posterior half.

(Belgovsky, 1937)

Posterior third or half of eye of heterozygote rough; facets irregular and fused. Homozygous lethal. Stocks vary in expression, presumably because of genetic modifiers. X/X and X/0 flies that are sv^spa-Cat/spa show the bulging eyes and roughening of spa and the posterior fused facets of sv^spa-Cat; X/X/Y and X/Y flies have only the sv^spa-Cat phenotype. sv^spa-Cat/sv^spa-pol has fusion of facets over entire surface of eye and roughness in posterior region of eye. sv^spa-Cat/4-sim is wild type. sv^spa-Cat/+ more extreme than sv^spa-Cat/+/+ (Davis, 1969). RK2. sv^spa-Cat behaves as a deficiency in that it fails to complement l(4)102EFa, l(4)102EFb, l(4)102EFc and l(4)102EFd; complements sv and l(4)102EFe.