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General Information
Symbol
Dmel\sr1
Species
D. melanogaster
Name
FlyBase ID
FBal0016068
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
sr
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Carried on aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygotes exhibit a significant reduction in DLM size.

Homozygotes have muscular and cuticular defects. Double heterozygotes with sr5, sr6, sr155, Df(3R)P14, sr461, srR947, sr61j and srbsc have muscular and cuticular defects.

Homozygotes are flightless, and have a normal wing posture.

sr1/sr61j show a variable sr phenotype that overlaps with wild-type.

Trident pattern on thorax replaced by broad light gray stripe at 25oC; stripe is dark at 18oC or in the presence of heterozygous or homozygous b or e. Homozygotes are flightless (Levine and Wyman, 1973) and show a reduction in size of a specific indirect flight muscle, the dorsal longitudinal muscle (DLM). The DLM is absent from sr1/Df(3R)sr- adults. Early development of the indirect flight muscles is normal, but in the thirty-five-hour pupa the DLM begins to degenerate leading to its absence in adults (Costello and Wyman, 1986).

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

sr1 is an enhancer of visible phenotype of acHw-1

Phenotype Manifest In
Enhancer of
Statement
Reference

sr1 is an enhancer of mesothoracic tergum & macrochaeta | ectopic phenotype of acHw-1

Additional Comments
Genetic Interactions
Statement
Reference

acHw-1 ; sr1 double mutant flies have a broader distribution of ectopic bristles over the notum than in flies mutant for acHw-1 alone. This effect is synergistic; the double mutant displays more bristles than the sum of the two single mutants.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (1)
Stocks (198)
Notes on Origin
Discoverer

Bridges, Feb. 1922.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (16)