FlyBase Allele Report: Dmel\sr[1]

General Information

Symbol

Dmel\sr¹

Species

D. melanogaster

Name

FlyBase ID

FBal0016068

Feature type

allele

Associated gene

Dmel\sr

Associated Insertion(s)

Carried in Construct

Also Known As

Key Links

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

(Lee et al., 1995)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

flightless | recessive

(Homyk and Emerson, 1988)

viable

(Usui et al., 2004)

Phenotype Manifest In

dorsal longitudinal indirect flight muscle cell

(Lee et al., 1995)

Detailed Description

Statement

Reference

Homozygotes exhibit a significant reduction in DLM size.

(Lee et al., 1995)

Homozygotes have muscular and cuticular defects. Double heterozygotes with sr⁵, sr⁶, sr¹⁵⁵, Df(3R)P14, sr⁴⁶¹, sr^R947, sr^61j and sr^bsc have muscular and cuticular defects.

(de la Pompa et al., 1989)

Homozygotes are flightless, and have a normal wing posture.

(Homyk and Emerson, 1988)

sr¹/sr^61j show a variable sr phenotype that overlaps with wild-type.

(Puro, 1982)

Trident pattern on thorax replaced by broad light gray stripe at 25^oC; stripe is dark at 18^oC or in the presence of heterozygous or homozygous b or e. Homozygotes are flightless (Levine and Wyman, 1973) and show a reduction in size of a specific indirect flight muscle, the dorsal longitudinal muscle (DLM). The DLM is absent from sr¹/Df(3R)sr^- adults. Early development of the indirect flight muscles is normal, but in the thirty-five-hour pupa the DLM begins to degenerate leading to its absence in adults (Costello and Wyman, 1986).

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

sr¹ is an enhancer of visible phenotype of ac^Hw-1

(Usui et al., 2004)

Phenotype Manifest In

Enhancer of

Statement

Reference

sr¹ is an enhancer of mesothoracic tergum & macrochaeta | ectopic phenotype of ac^Hw-1

(Usui et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

ac^Hw-1 ; sr¹ double mutant flies have a broader distribution of ectopic bristles over the notum than in flies mutant for ac^Hw-1 alone. This effect is synergistic; the double mutant displays more bristles than the sum of the two single mutants.

(Usui et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (1)

Holtzman, S. and Kaufman, T. (2013)

Mutant

Wild-type