FB2026_02 , released June 18, 2026
Allele: Dmel\srw1
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General Information
Symbol
Dmel\srw1
Species
D. melanogaster
Name
FlyBase ID
FBal0016083
Feature type
allele
Associated gene
Dmel\srw
Associated Insertion(s)
Carried in Construct
Also Known As
srw10K
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Amino acid replacement: C123S.

(Bonds et al., 2007)

Nucleotide substitution: T?A.

(Bonds et al., 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:4,283,112..4,283,112 [-]
Nucleotide change:

T4283112A

Reported nucleotide change:

T?A

Amino acid change:

C123S | srw-PB

Reported amino acid change:

C123S

(Bonds et al., 2007)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Approximately one fourth of the embryos from a cross of srw1 males to Df(3L)Exel9000 females are strongly ventralized.

      Mutant embryos are ventralized.

      (Bonds et al., 2007)

      Weak ventralised phenotype. Defective movements of the germ band: due to loss of the amnioserosa and because the dorsalmost cells have acquired the lateral fate of the dorsal ectoderm.

      (Arora and Nusslein-Volhard, 1992)

      srw1 embryos are partially ventralised.

      (Tearle and Nusslein-Volhard, 1987)

      embryonic lethal embryos partially ventralized.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      References (7)