FlyBase Allele Report: Dmel\ss[aP88]

General Information

Symbol

Dmel\ss^aP88

Species

D. melanogaster

Name

FlyBase ID

FBal0016120

Feature type

allele

Associated gene

Dmel\ss

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

X ray

Nature of the Allele

Allele class

loss of function allele

(Duncan et al., 1998)

Mutagen

X ray

Progenitor genotype

Caused by aberration

In(3LR)P88

Cytology

Description

Inversion breakpoint (89C2-4 breakpoint of In(3LR)P88) within ss. The 5' end of this breakpoint corresponds to 3R:16383781 and the 3' end corresponds to 3R:16383775 (release 6 coordinates), meaning that there is a 7bp duplication of genomic sequence, in addition to the inversion.

(Miller et al., 2016)

Break falls between coordinate +20 and (approximately) +17kb on the ss molecular map, within the ss transcription unit.

(Duncan et al., 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

flightless | recessive

(Kirpichnikova, 1992)

visible (with ss¹)

(Miller et al., 2020)

visible | homeotic

(Duncan et al., 1998)

visible | homeotic | recessive

(Kirpichnikova, 1992)

visible | recessive

(Struhl, 1982)

Phenotype Manifest In

antenna

(Duncan et al., 1998, Struhl, 1982)

arista

(Kirpichnikova, 1992, Struhl, 1982)

chaeta (with ss¹)

(Miller et al., 2020)

macrochaeta

(Duncan et al., 1998, Struhl, 1982)

mesothoracic tarsal segment | distal | ectopic

(Kirpichnikova, 1992)

tarsal segment

(Duncan et al., 1998, Struhl, 1982)

third segment of antenna

(Struhl, 1982)

Detailed Description

Statement

Reference

Null phenotype. Antennal transformations, reduction in bristle size and tarsal deletions.

(Duncan et al., 1998)

ss^aP88 in combination with ss^a, ss^aB, ss^ax or ss^a40a produces transformation of the arista to distal mesothoracic tarsus. The expressivity of the phenotype decreases with increasing temperature in ss^aB/ss^aP88 flies. A high proportion of ss^a40a/ss^aP88 or ss^a/ss^aP88 flies produce an ectopic tarsal response to chemical stimulation at 25^oC. ss^a/ss^aP88 and ss^ax/ss^aP88 flies usually cannot fly, although ss^aB/ss^aP88 and ss^a40a/ss^aP88 flies often show some flight ability.

(Kirpichnikova, 1992)

ss^aC3/ss^aP88 flies are viable and fertile, and have a modest aristapedia phenotype; the proximal portion of the arista is swollen and carries bracted bristles characteristic of the tarsus. Bracted bristles are also found on the distal portion of the third antennal segment. ss^a/ss^aP88 flies have an aristapedia phenotype; the arista and part of the third antennal segment are transformed into a well formed distal leg carrying 2 claws and 3 to 4 tarsal segments. ss^aP88 is viable in transheterozygous combination with either ss^aC6, ss^aC10, ss^aC11, ss^aC13, Df(3R)ss-a or ss^aC16, and gives the following phenotype; flies show complete transformation of the distal antenna to distal tarsus. Bristles show and extreme and consistent spineless phenotype. Fusions of most of the tarsal segments of the legs and also of the transformed aristapedia tarsus are seen. ss^aP88 is viable in transheterozygous combination with either ss^aC5, ss^aC7, ss^aC8, ss^aC9, ss^aC12 or ss^aC14 producing flies with an aristapedia phenotype.