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General Information
Symbol
Dmel\tipE1
Species
D. melanogaster
Name
FlyBase ID
FBal0016803
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

T4191305A

Reported nucleotide change:

T714A

Amino acid change:

C238term | tipE-PA; C238term | tipE-PB

Reported amino acid change:

C238term

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution: T714A.

Amino acid replacement: C238term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
ameliorates  epilepsy
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Mutant flies show a slightly increased tolerance to the paralytic effect of the toxin AaIT compared to wild-type flies.

Shows no temperature sensitive ERG on/off transients mutant phenotype.

The courtship song parameters interpulse interval and cycles per pulse are normal in homozygous males at 25oC, but the interpulse frequency and amplitude of sound are significantly lower than in wild-type males at 25oC.

When heterozygous with Df(3L)TE1, T(2;3)TE2 or Df(3L)TE3 individuals exhibit a temperature-induced paralytic phenotype.

Mutant becomes paralyzed rapidly at 38oC; recovers within seconds when temperature is lowered. No apparent increase in recovery times with longer exposure to high temperature (Jackson, Wilson and Hall, 1986). When in a double mutant combination with parats1, tipE results in action potential failures in recordings from larval motor neurons at 33oC, a temperature at which either parats1 or tipE alone seems to have normal nerve conduction (Ganetzky, 1986). Adult action potential failures in mlenap-ts1; tipE double mutants occur at a lower temperature (31oC) than in wild type (Ganetzky, 1986); flies of this double-mutant genotype exhibit poorer viability and become paralyzed at lower temperatures than either mutant alone. The parats1; tipE double mutants also survive poorly, showing unconditional lethality in combinations with certain para alleles; In para/+; tipE/tipE mutants, para alleles become semidominant for heat-induced paralysis (Ganetzky, 1986). Biochemically, tipE leads to reduced levels of saxitonin binding activity (not temperature-dependent) in adult head extracts, but the dissociation constants for such binding is normal (Jackson, Wilson and Hall, 1986). The mutant is slightly resistant to veratrine and shows enhanced tetrodotoxin sensitivity (Jackson et al., 1986). Sodium current density in cultured embryonic neurons is about half that recorded using 'tight-seal' techniques from wild-type cells (O'Dowd and Aldrich, 1988). When rather lengthy heat treatments are given to sei1, the fairly long recovery times are partially suppressed by tipE. Partial suppression of Sh-induced leg shaking is also effected by tipE (Jackson, Wilson and Hall, 1986).

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

tipE1 is a suppressor of bang sensitive phenotype of parabss1

NOT Suppressor of
Statement
Reference

tipE1 is a non-suppressor of bang sensitive phenotype of parabss1

Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The penetrance of the bang sensitive phenotype seen in parabss1/+ females is significantly reduced compared to controls in parabss1/+ tipE1/+ females and is reduced even further in parabss1/+ tipE1/tipE1 females. However, bang sensitive phenotype seen in parabss1/Y males is not suppressed in parabss1/Y tipE1/tipE1 males.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (7)