FB2026_02 , released June 18, 2026
Allele: Dmel\tld2
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General Information
Symbol
Dmel\tld2
Species
D. melanogaster
Name
FlyBase ID
FBal0016873
Feature type
allele
Associated gene
Dmel\tld
Associated Insertion(s)
Carried in Construct
Also Known As
tld6B69, tld6B
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Finelli et al., 1994)
Mutagen
ethyl methanesulfonate
(Finelli et al., 1994, Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

The mutation falls in the C4 domain of the tld protein.

(Finelli et al., 1994)

Amino acid replacement: E839K.

(Finelli et al., 1994)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:24,752,761..24,752,761 [+]
Nucleotide change:

G24752761A

Reported nucleotide change:

G?A

Amino acid change:

E849K | tld-PA

Reported amino acid change:

E839K

Comment:

Position of mutation on reference sequence inferred by FlyBase curator. Difference beteween actual and reported amino acid substitution due to authors using M11 as the start Met.

(Finelli et al., 1994)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Neuromuscular junctions appear normal in structure and localisation in tld2/tld7074 and tld2/tld9 third instar larvae.

      (Meyer and Aberle, 2006)

      Embryos heterozygous for tld loss of function mutants show normal activation of Mad.

      (Eldar et al., 2002)

      Weak ventralization.

      (Finelli et al., 1994)

      Weak ventralised phenotype. Defective movements of the germ band: due to loss of the amnioserosa and because the dorsalmost cells have acquired the lateral fate of the dorsal ectoderm. Dorsal cell fates are deleted and ventrolateral mitotic domains are expanded.

      (Arora and Nusslein-Volhard, 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Weak phenotype can be completely suppressed by duplication of dpp+.

      (Ferguson and Anderson, 1992)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Weak, incompletely penetrant tld allele.

      (Ferguson and Anderson, 1992)

      Weak tld allele. Four copies of P{tldP/tlr-1} are unable to rescue the mutant phenotype.

      (Nguyen et al., 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      References (10)