FB2026_02 , released June 18, 2026
Allele: Dmel\tsl5
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General Information
Symbol
Dmel\tsl5
Species
D. melanogaster
Name
FlyBase ID
FBal0017199
Feature type
allele
Associated gene
Dmel\tsl
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Savant-Bhonsale and Montell, 1993, Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Amino acid replacement: Y148N.

(Savant-Bhonsale and Montell, 1993)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:21,778,972..21,778,972 [-]
Nucleotide change:

T21778972A

Amino acid change:

Y148N | tsl-PA; Y148N | tsl-PB; Y148N | tsl-PC

Reported amino acid change:

Y148N

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Savant-Bhonsale and Montell, 1993)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Late embryos from tsl5/tslΔ transheterozygous mothers exhibit a fully penetrant "terminal class mutant" phenotype, in which some terminal structures are missing (including head structures, abdominal segment 8, telson, and filzkorper), and exhibit a highly penetrant posterior-ventral cuticle hole phenotype, as compared to controls.

      (Johnson et al., 2017)

      tslΔ/tsl5 mutant transheterozygotes are significantly delayed in reaching pupariation compared with controls.

      (Johnson et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      tsl5 is rescued by tsltor.PF

      (Furriols et al., 1998)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Allelic series: tsl5 = tsl4 > tsl3 > tsl1 > tsl2

      (Savant-Bhonsale and Montell, 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      References (6)