FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\tt1
Open Close
General Information
Symbol
Dmel\tt1
Species
D. melanogaster
Name
FlyBase ID
FBal0017201
Feature type
allele
Associated gene
tt
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    The tt1 allele contains a gtwin transposon (which contains su(Hw) insulator binding sites) within a genomic region that contains cis-regulatory elements that control expression of the Iroquois Complex genes ara and caup in the wing hinge and wing veins (this cis-regulatory region is located within an intron of sowah, but complementation analysis shows that tt1 is not a loss of function allele of sowah). Mutations in su(Hw) suppress the mutant phenotype of su(Hw), suggesting that this gtwin transposon may be responsible for the tt1 mutant phenotype.

    (Gruber et al., 2025)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Mutant flies do not show significantly increased survival compared to wild-type flies after infection with E. chaffeensis.

        (Von Ohlen et al., 2012)

        Low penetrance, small intercalary gaps in LIII.

        (Diaz-Benjumea and Garcia-Bellido, 1990)

        Developmentally, L3 originally complete but central section disappears during contraction period.

        (Waddington, 1940)

        Eye colour: may be slightly dilute. Wings spread, elevated and warped in a compound curve. Vein L3 shows gap.

        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressed by
        Statement
        Reference

        tt1 has visible phenotype, suppressible by su(Hw)8/su(Hw)8

        (Gruber et al., 2025)
        Other
        Statement
        Reference

        su(r)unspecified, tt1 has lethal phenotype

        (Stroman, 1974)
        Phenotype Manifest In
        Enhanced by
        Statement
        Reference

        tt1 has phenotype, enhanceable by Egfrt1/Egfrf11

        (Diaz-Benjumea and Garcia-Bellido, 1990)
        Suppressed by
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        tt1 EgfrE3 double homozygotes show a simple additive phenotype. Egfrt1/Egfrf11 tt1/tt1 double mutants have a superadditive phenotype.

        (Diaz-Benjumea and Garcia-Bellido, 1990)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (2)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        tilt1
        (Gruber et al., 2025)
        tt
        (Diaz-Benjumea and Garcia-Bellido, 1990)
        tt1
        (Von Ohlen et al., 2012, Pilgram et al., 2011)
        Name Synonyms
        Secondary FlyBase IDs
          References (7)