FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\twi3
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General Information
Symbol
Dmel\twi3
Species
D. melanogaster
Name
FlyBase ID
FBal0017299
Feature type
allele
Associated gene
Dmel\twi
Associated Insertion(s)
Carried in Construct
Also Known As
twiIIH, twiIIH07
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Tearle and Nusslein-Volhard, 1987, Simpson, 1983)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In twi3, sna19 double mutants fail to form a regular midgut epithelium. However the segregation into principal midgut epithelial cells, large basophilic midgut cells and adult midgut precursors still occurs.

      (Tepass and Hartenstein, 1995)

      Endodermal primordium fails to invaginate, though during the course of germ band extension cells ingress into the embryo and attach to the posterior surface of the stomodeum. Thus even though the early morphogenesis of the anterior midgut is abnormal, the lack of twi function is without consequence for the ultimate fate of the anterior midgut.

      (Reuter and Leptin, 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The stomatogastric nervous system is intact in twi3 sna18 double mutant stage 16 embryos, but the corpus cardiacum is absent.

      (De Velasco et al., 2004)

      Embryos mutant for both sna and twi do not form an anterior midgut or a stomodeum.

      (Reuter and Leptin, 1994)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      C. Nusslein-Volhard.

      (Simpson, 1983)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      References (19)