FB2026_02 , released June 18, 2026
Allele: Dmel\Ubxbx-8
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General Information
Symbol
Dmel\Ubxbx-8
Species
D. melanogaster
Name
FlyBase ID
FBal0017519
Feature type
allele
Associated gene
Dmel\Ubx
Associated Insertion(s)
Harvey{}Ubxbx-8
Carried in Construct
Also Known As
bx8
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Peifer and Bender, 1986, Lewis, 1980)
Progenitor genotype
Associated Insertion(s)
Harvey{}Ubxbx-8
Cytology

Polytene chromosomes normal.

(Castelli-Gair and Garcia-Bellido, 1990)
Description

Insertion of Harvey element into the bx regulatory region.

(Castelli-Gair and Garcia-Bellido, 1990)

Insertion of a Harvey element.

(Micol et al., 1990)

Harvey insertion at -59.5kb of the Ubx locus.

(Peifer and Bender, 1986)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Ubx6.28/Ubxbx-8 mutant combinations cause a homeotic transformation of the third thoracic segment to the anterior second thoracic segment. The haltere (T3) is also transformed toward wing fate (T2), manifested by increases in size and the development of bristles.

      (Badenhorst et al., 2002)

      Does not affect the frequency of the trx bithorax-variegated phenotype in heterozygous combination with Df(3R)red-P52.

      (Castelli-Gair and Garcia-Bellido, 1990)

      Homozygotes and transheterozygotes of Ubx alleles demonstrate a significant enhancement of the bx phenotype when in combination with E(bx)2. Haltere to winglike and metanotum to mesonotumlike transformations are enhanced.

      (Bhosekar and Babu, 1987)

      Haltere are transformed to wing and are 20-30% of wing size, dorsal tissue of T3 is incompletely transformed to metanotum, hypopleural plates are incompletely transformed to sternopleural plates, 9-10 hypopleural bristles are still present and the anterior third leg displays a strong transformation to anterior second leg, as seen by the bristle pattern.

      (Peifer and Bender, 1986)

      Phenotype is not suppressed by su(Hw)2.

      (Lewis, 1980)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The addition of E(bx)Nurf301-2 or Df(3L)3643 to Ubxbx-8/Ubx6.28 animals enhances the anterior transformation seen in both the third thoracic segment and the haltere.

      (Badenhorst et al., 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Lewis, 1965.

      (Lewis, 1980)

      Lewis.

      (Peifer and Bender, 1986)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      References (9)