FlyBase Allele Report: Dmel\v[36f]

General Information

Symbol

Dmel\v^36f

Species

D. melanogaster

Name

FlyBase ID

FBal0017676

Feature type

allele

Associated gene

Dmel\v

Associated Insertion(s)

roo{}v^36f

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

Progenitor genotype

Associated Insertion(s)

roo{}v^36f

Cytology

Description

Insertion of a roo element between base pairs 2298 and 2299, in the fourth intron near the splice donor site. The direction of transcription of the roo element is the same as that of the v gene.

(Searles et al., 1990)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:10,925,154..10,925,154 [+]

(Fridell and Searles, 1994, Fridell and Searles, 1991, Searles et al., 1990)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Campesan et al., 2011)

exacerbates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Breda et al., 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color

(Zhimulev et al., 1987)

long lived

(Maddison et al., 2020)

visible | recessive

(Zhimulev et al., 1987)

Phenotype Manifest In

ocellus pigment granule

(Tearle, 1991)

pigment cell

(Zhimulev et al., 1987)

Detailed Description

Statement

Reference

Synthesis of 3-hydroxykynurenine (3-HK) is essentially eliminated in v^36f mutant flies at day one post-eclosion, whereas kynurenic acid (KYNA) levels increased, leading to a dramatic decrease in the 3-HK/KYNA ratio.

(Campesan et al., 2011)

Eye colour: peach. Some individuals transformed with P{YC1.8} survive to adulthood and most are fertile, transformants have a dull red eye colour phenotype.

(Fridell and Searles, 1991)

Ocellus colour: colourless.

(Tearle, 1991)

Eye colour: vermilion.

(Zhimulev et al., 1987)

Fly from starved larva does not form brown eye pigment.

(Green, 1954)

Malpighian tubule colour: pale yellow.

(Brehme and Demerec, 1942)

Eye colour: bright red; may be slightly more yellow than v¹. RK1.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

v^36f is a suppressor of abnormal neuroanatomy | adult stage phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Campesan et al., 2011)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

v^36f has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

v^36f has phenotype, non-suppressible by su(sable)¹

(Green, 1952)

Suppressor of

Statement

Reference

v^36f is a suppressor of rhabdomere phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Campesan et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Homozygous v^36f partially suppresses the rhabdomere degeneration seen in one day old flies when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^elav-C155. Some rescue, albeit reduced, is also seen at seven days post-eclosion. Partial rescue is also seen with v^36f/+. The increase in 3-hydroxykynurenine (3-HK)/kynurenic acid (KYNA) ratio is also significantly suppressed with either homozygous or heterozygous v^36f, with flies exhibiting ratios that are similar to those seen in homozygous v^36f mutant flies alone.

(Campesan et al., 2011)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (3)

Bloomington

142

v^36f

3611

y^59b dor^84k z¹ lz^50e v^36f