FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\wDZL
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General Information
Symbol
Dmel\wDZL
Species
D. melanogaster
Name
Dominant zeste-like
FlyBase ID
FBal0018236
Feature type
allele
Associated gene
Dmel\w
Associated Insertion(s)
FB{}wDZL
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
(Zachar and Bingham, 1982)
Progenitor genotype
Associated Insertion(s)
FB{}wDZL
Caused by aberration
Dp(2;1)wDZL
Cytology
Description

Insertion of FB sequences into the upstream regulatory region of w.

(Bhadra et al., 1997)

Caused by a foldback element upstream of the normal regulatory sequences of w.

(Rabinow et al., 1991)

Insertion of FB element.

(Harden and Ashburner, 1990)

Insertion of a composite transposon 5-6kb 5' to w, resulting in a novel transcription unit that is expressed in the head. The transposon consists of a 6.5kb portion, originating at cytological locus 21D, flanked by two FB transposons.

(Bingham and Zachar, 1985)

Insertion of a 13 kb FB-element at map position +9.8 relative to the transcription start site of w.

(Collins et al., 1983)

FB insertion between coordinates +9.5 and +10, using coordinate system of FBrf0038648 where coordinate 0 is the copia insert of wa.

(Zachar and Bingham, 1982)

Physical analysis of wDZL shows that the mutant phenotype results from the insertion (proximal to white) of a complex transposable element made up of sequences normally found at 21D ('unique segment sequences') flanked by sequences of two FB transposons (Levis et al., 1982; Zachar and Bingham, 1982; Bingham and Zachar, 1985). A transcript 1.3 kb larger than the major (2.6 kb) w+ transcript is found in wDZL adult heads and head precursor tissues; this is a composite transcript, made up of sequences from the major w+ transcript and from the wDZL unique segment (Bingham and Zachar, 1985; Zachar, Chapman and Bingham, 1985). In wDZL flies, a reduction in the levels of the w+ transcript is observed in adult head and head precursor tissues, but not in abdominal tissues. Revertants of wDZL show loss of most of the unique segments of the insertion with 1.9 and 6.2 kb of the insertion remaining (Levis and Rubin, 1982; Zachar and Bingham, 1982). 13kb FB insertion map site (kb): +9.77; Origin = insertion of wa copia; '-' values to left (telomere) end; '+' values to right (centromere) end.

Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Eye colour: z-like. Shows some interaction with Inr-a mutants.

      (Rabinow et al., 1991)

      Eye colour: dull red brown, in z+ males. Eye colour: yellow, in heterozygous or homozygous females. Eye colour: wild-type in In(1)wDZL-1/wDZL, T(1;3)wDZL/wDZL females. Eye colour: wild-type in In(1)wDZL-3/wDZL females.

      (Bingham, 1981)

      Eye colour: dull red brown, in z+ males. Eye colour: yellow, in z1 males and in homo- and heterozygous females (z+ or z1) when X's synapsed. Malpighian tubule colour: wild-type. Testis colour: wild-type.

      (Bingham, 1980)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      wDZL has abnormal eye color phenotype, enhanceable by Low1

      (Bhadra et al., 1997)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      wDZL has pigment cell phenotype, enhanceable by Low1

      (Bhadra et al., 1997)

      wDZL has phenotype, enhanceable by Wowγb

      (Birchler et al., 1994)

      wDZL has phenotype, enhanceable by Wowγe

      (Birchler et al., 1994)

      wDZL has phenotype, enhanceable by Wowems1

      (Birchler et al., 1994)

      wDZL has phenotype, enhanceable by Wowhd1

      (Birchler et al., 1994)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Female progeny of w+ crossed to wDZL, Wow- have reduced eye pigment. When z1 wDZL are crossed to Wow mutants, Wow has no effect on the eye color of sons.

      (Birchler et al., 1994)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (3)
      Notes on Origin
      Discoverer

      Bingham.

      Comments
      Comments

      wDZL shows synapsis-dependent dominance over w+. It is a highly mutable allele (like wc), giving rise spontaneously to w+ and w- derivatives with a frequency of 0.5-1.5%.

      (Bingham, 1980)

      Located in or immediately proximal to the rightmost set of previously-defined w mutant sites Mutable allele; spontaneous mutations are observed at a frequency of 0.5 to 1.5%.

      (Bingham, 1981)

      Unstable mutation that creates revertants that carry internal deletion of the FB element.

      (Zachar and Bingham, 1982)

      Unstable.

      (Harden and Ashburner, 1990)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      wDZL
      Name Synonyms
      Dominant zeste-like
      Secondary FlyBase IDs
        References (18)