FlyBase Allele Report: Dmel\wrl[1]

General Information

Symbol

Dmel\wrl¹

Species

D. melanogaster

Name

FlyBase ID

FBal0018530

Feature type

allele

Associated gene

wrl

Associated Insertion(s)

Carried in Construct

Also Known As

nc4

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Green et al., 1990, Fuller, 1986)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

male sterile | recessive

(Green et al., 1990, Fuller, 1986)

viable

(Fuller, 1986)

Phenotype Manifest In

spermatid axoneme

(Fuller, 1986)

Detailed Description

Statement

Reference

Heterozygotes with Df(3R)red3l are fertile. Female homozygotes are viable and fertile and male homozygotes have a defect in spermatid flagella axoneme structure.

(Green et al., 1990)

primary spermatocytes from homozygous males appear to undergo meiosis normally; onion stage cysts have the regular array of uniformly sized nuclei and mitochondrial derivatives. Axonemes are defective, lacking the accessory tubule and its associated beak-shaped projection which normally grows from the B-subfibre of each outer doublet. The axonemes therefore lack the pinwheel pattern typical of normal mid-to-late stage axonemes.

(Fuller, 1986)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

wrl¹ is an enhancer of male sterile | dominant phenotype of βTub85D¹¹

(Green et al., 1990)

wrl¹ is an enhancer of male sterile | dominant phenotype of βTub85D³

(Green et al., 1990)

wrl¹ is an enhancer of male sterile | dominant phenotype of βTub85D¹⁰

(Green et al., 1990)

wrl¹ is an enhancer of male sterile | dominant phenotype of βTub85Dⁿ

(Green et al., 1990)

Other

Statement

Reference

βTub85D⁷, wrl¹ has male fertile phenotype

(Green et al., 1990)

βTub85D⁹, wrl¹ has male fertile phenotype

(Green et al., 1990)

Phenotype Manifest In

Enhancer of

Statement

Reference

wrl¹ is an enhancer of phenotype of βTub85D^unspecified

(Fuller, 1986)

Additional Comments

Genetic Interactions

Statement

Reference

Double heterozygotes with βTub85Dⁿ, βTub85D³, βTub85D¹⁰ and βTub85D¹¹ are sterile and with βTub85D⁶, βTub85D⁷ and βTub85D⁹ are fertile. Dominant enhancer of tubulin mutants.

(Green et al., 1990)

Fails to complement class I alleles at the βTub85D locus.

(Fuller, 1986)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: a mutation that fails to complement class I alleles at the βTub85D locus (either βTub85D³ or βTub85D^Drv1) but does not map to the βTub85D locus.

(Fuller, 1986)

Comments

wrl¹ fails to complement βTub85D¹⁰ and βTub85D¹¹ and complements βTub85D⁶, βTub85D⁷ and βTub85D⁹.

(Green et al., 1990)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

EcRms4

(Green et al., 1990)

nc4

(Green et al., 1990, Fuller, 1986)

wrl¹

wrl^nc4

(Hawley and Gilliland, 2006)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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