FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\G6pdA
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General Information
Symbol
Dmel\G6pdA
Species
D. melanogaster
Name
FlyBase ID
FBal0018865
Feature type
allele
Associated gene
Dmel\G6pd
Associated Insertion(s)
Carried in Construct
Also Known As
G6pdF
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
Progenitor genotype
Cytology
Description

Nucleotide substitution: C1817T. Amino acid replacement: P382L.

(Eanes et al., 1996)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
sequence_variant
X:19,671,756..19,671,756 [+]
Nucleotide change:

C19565789T

Reported nucleotide change:

C1817T

Amino acid change:

P382L | G6pd-PA; P360L | G6pd-PB; P360L | G6pd-PC

Reported amino acid change:

P382L

Comment:

Mutation presumed to be responsible for electrophoretic variant.

(Eanes et al., 1996)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      ZwA has statistically lower (by 32%) pentose shunt flux than ZwB at 25oC.

      (Labate and Eanes, 1992)

      Fast electrophoretic variant.

      (Nero et al., 1989)

      electrophoretic variant: fast

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Young.

      Comments
      Comments

      Fast electrophoretic variant.

      (Kogan et al., 1981)

      Populations selected for a short lifespan contain the ZwA allele, in contrast to populations selected for a long lifespan, which contain the ZwB allele.

      (Luckinbill et al., 1990)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      G6pd6
      G6pdA
      G6pdF
      (Capy et al., 2000, Bubliy et al., 1999)
      ZwA
      Zwf
      Name Synonyms
      Secondary FlyBase IDs
        References (11)