Luckinbill, L.S., Riha, V., Rhine, S., Grudzien, T.A. (1990). The role of glucose-6-phosphate dehydrogenase in the evolution of longevity in Drosophila melanogaster.  Heredity 65(1): 29--38.

FBrf0052084

Research paper

Different polymorphic elements of the enzyme glucose-6-phosphate dehydrogenase (G6PD) are favoured under selection for long versus short life span. Replicate independently selected populations of short-lived individuals exhibit a more rapidly migrating and less actively staining allozyme, while long-lived populations have a slower migrating and more active allozyme. These correspond to the common ZwA and ZwB variants of the G6PD locus Zw. In vitro measurements show G6PD activity varies with allozymes and life span. Long-lived males have 64 per cent greater activity in G6PD, while females of long-lived strains are 108 per cent higher than those of short-lived strains. Previous studies of these strains have repeatedly demonstrated additivity of life span in F1 crosses. Activity of G6PD in reciprocal F1 populations is additive and intermediate between parents.