FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\can1
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General Information
Symbol
Dmel\can1
Species
D. melanogaster
Name
FlyBase ID
FBal0020008
Feature type
allele
Associated gene
Dmel\can
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Contains a deletion of bps 2281 to 2479 that leads to an in frame deletion of amino acids 746-811. This removes one and a half of the conserved WD40 repeats.

    (Hiller et al., 2001)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    deletion
    3L:10,264,383..10,264,580 [-]
    Comment:

    An in frame deletion of 66 amino acids from aa746–811. Position of mutation on reference sequence inferred by FlyBase curator based on author statement.

    (Hiller et al., 2001)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Early stages of spermatogenesis up through mature primary spermatocytes are present and normal. Postmeiotic stages are completely absent. Mutant testes have an abundance of mature primary spermatocytes with large, round nuclei and prominent nucleoli. Triple mutant aly1, can1, sa1 homozygotes are female fertile and male sterile, with similar effects on testis squashes as sa1 and can1. Spermatocytes arrest in the G2/M transition of meiosis I with partial chromosome condensation.

        (Lin et al., 1996)

        male-sterile No meiotic divisions or postmeiotic stages; spermatocytes accumulate.

        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        Comments
        Comments

        Not associated with a detectable P-element insertion at the aly locus.

        (Lin et al., 1996)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        can1
        (Laktionov et al., 2018)
        Name Synonyms
        Secondary FlyBase IDs
          References (6)