FlyBase Allele Report: Dmel\rst[irreC2]

General Information

Symbol

Dmel\rst^irreC2

Species

D. melanogaster

Name

FlyBase ID

FBal0025338

Feature type

allele

Associated gene

Dmel\rst

Associated Insertion(s)

Carried in Construct

Also Known As

irreC^1R34

Key Links

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Fischbach, 2001.12.10, Ramos et al., 1993, Boschert et al., 1990)

Progenitor genotype

Caused by aberration

In(1)irreC-IR34

Cytology

Description

Proximal inversion breakpoint interrupts the 5' leader sequence of the rst transcript.

(Reddy et al., 1999)

Proximal breakpoint breaks within intron 2.

(Ramos et al., 1993)

Inversion breakpoint lies within the 5' untranslated region.

(Ramos et al., 1993)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile

(Boschert et al., 1990)

Phenotype Manifest In

Detailed Description

Statement

Reference

The pattern of apoptotic nuclei in third larval instar antennal discs is no different from wild type.

(Reddy et al., 1999)

Aberrant axonal projections.

(Ramos et al., 1993)

Severe disorder of second optic chiasm. Weak eye roughening. Absence anterior vertical and anterior dorso central bristles.

(Boschert et al., 1990)

shows high penetrance for optic-lobe abnormalities, but variable expressivity; females homozygous for this inversion (see below) do not lay eggs and have rudimentary egg chambers (likely not due to lesion in region 3C, owing to fertility of synthetic deletion described under cytology).

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

rst^irreC2 has phenotype, enhanceable by Delta^E58

(Gorski et al., 2000)

rst^irreC2 has phenotype, enhanceable by Delta^J17

(Gorski et al., 2000)

rst^irreC2 has phenotype, enhanceable by Delta^K75

(Gorski et al., 2000)

rst^irreC2 has phenotype, enhanceable by Delta^J111

(Gorski et al., 2000)

rst^irreC2 has phenotype, enhanceable by Delta^HD82

(Gorski et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

1R34

(Fischbach, 2001.12.10)

irreC-rst^IR34

(Gorski et al., 2000)

irreC2

(Fischbach, 2001.12.10)

irreC^1R34

(Sugie et al., 2010, Schneider et al., 1995, Ramos et al., 1993)

irreC²

irreC^IR34

(Araujo et al., 1996, Ramos et al., 1993, Ramos et al., 1991, Ramos et al., 1991, Boschert et al., 1990)

rst^irreC1R34

(Simon et al., 2009)

rst^irreC2

Name Synonyms

Secondary FlyBase IDs

References (13)

Report Sections

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